| Model No. | Nomenclature | Genotype |
|---|---|---|
| 1349-F | B6;SJL-Tg(APPSWE)2576Kha | tg/wt |
| 1349-M | B6;SJL-Tg(APPSWE)2576Kha | tg/wt |
| 1349-F | B6;SJL-Tg(APPSWE)2576Kha | wt/wt |
| 1349-M | B6;SJL-Tg(APPSWE)2576Kha | wt/wt |
| 1349-RD1-F | B6;SJL-Tg(APPSWE)2576Kha | tg/wt |
| 1349-RD1-M | B6;SJL-Tg(APPSWE)2576Kha | tg/wt |
| 1349-RD1-F | B6;SJL-Tg(APPSWE)2576Kha | wt/wt |
| 1349-RD1-M | B6;SJL-Tg(APPSWE)2576Kha | wt/wt |
APPSWE - Model 1349
View:
Select One
- Description
- Related Products & Services
- Price & Licensing
- Health Report
- Overview
- Genetics
- Guides & Publications
- Applications & Therapeutic Areas
- Transit, Housing & Welfare
- Diet
Overview
Nomenclature: B6;SJL-Tg(APPSWE)2576Kha
- Carries a transgene coding for the 695-amino acid isoform of human Alzheimer β-amyloid (Aβ) precursor protein carrying the Swedish mutation
- Expresses high concentrations of the mutant Aβ, develops significant amyloid plaques and displays memory deficits
- Useful for the study of APP expression, amyloid plaque formation, neuronal decline and memory loss associated with Alzheimer's disease (AD) as well as the study of drugs designed for treatment or prevention of Alzheimer's disease
- Pink eyed animals, associated with certain coat colors, and the Pde6brd1 retinal degeneration mutation can cause light sensitivity and/or blindness in some animals. This may impact the results of behavioral testing. Upon request, animals can be screened for eye color, coat color, and/or rd1 homozygosity for an additional fee
- Rd1 tested mice (1349-RD1-F and 1349-RD1-M) are wild type or heterozygous for the Pde6brd1 mutation. Genotype shown in the table above refers to the APPSWE transgene.
Orders by weight: Taconic cannot accept orders by weight for this model. Please note that shipments may contain animals with a larger weight variation.
Origin
Genetics
Guides & Publications
Initial Publication: Hsaio K, Chapman P, Nilsen S, Eckman C, Harigaya Y, Younkin S, Yang F, Cole G. (1996) Correlative memory deficits, Aβ elevation, and amyloid plaques in transgenic mice. Science, 274:99-102.
Applications & Therapeutic Areas
- Alzheimers Disease
- Genetically Humanized
- Neuroscience
- Psychiatric Disorders
Transit, Housing & Welfare
Need more info? Click the live chat button or Contact Us
- Premature mortality is an expected phenotype of this line, with mortality of 20% anticipated, particularly in males. Please take this into consideration when deciding upon order size to retain the needed experimental group size
- Shipping Guidelines: Taconic recommends that customers purchase mice between 10 and 12 weeks of age. Due to a phenotype of sudden death at young ages, Taconic cannot guarantee shipment of mice 9 weeks of age or younger.
- Between 7 to 12 weeks of age males become aggressive and begin to fight. Male APPSWE mice are shipped in divided Taconic Transit Cages™ with one animal per section. We highly recommend housing APPSWE male mice one per cage.
- Barbering is common in this strain, particularly in older females, and is usually caused by over-grooming from a cagemate. Barbered animals display alopecia (hair loss) around the eyes, nose, head or back, which can range from mild hair loss to large areas of missing hair. Skin is typically not affected, and no medical treatment is indicated for hair loss caused by barbering. Because of the high incidence of barbering in this strain, animals with mild to moderate barbering may be included in shipments.
- APPSWE mice may develop circling behavior.
Hemizygous male 1349 mice are packed one per TTC section, with a maximum of 4 mice per TTC. Wild type 1349 mice are packed as cagemates, one cage per Taconic Transit Cage (TTC). Customers should take care recombining 1349 males from different TTCs or TTC sections into the same cage at or after unpacking.
Packing Practices
Taconic standard practice is to recombine animals of different home cages and/or ages from a single model and sex during packing, except in specific cases where Taconic's animal welfare policy prohibits recombination due to aggression or other concerns. When an order is fulfilled with animals from more than one week of birth, this standard practice results in animals from a range of birth weeks packed together in a single TTC. When an order is fulfilled with animals from genotyped models, this standard practice results in animals from different home cages packed together in a single TTC.
Customers who wish to keep animals from different weeks of birth separated should place orders with the special instruction "Divide and label by age." Note that this special request can result in increased costs for additional Taconic Transit Cages, dividers and/or freight charges.
Taconic discourages other types of custom packing requests as they can have a negative impact on animal welfare. Learn more.
Diet
- Services
- Licensing
- Pricing - USD
- Pricing - EUR
- Pricing - USD Nonprofit
- Pricing - EUR Nonprofit
- Select my Health Standard
- Get Custom Pricing Guide
APPSWE - Model 1349
Conditions of Use for Taconic Transgenic Models™
Taconic Transgenic Models™ (Models) are produced and distributed under rights to patents and intellectual property licensed from various institutions. Taconic sells the Models to purchasers, grants to each purchaser a right under Taconic's rights in such licensed patents and intellectual property to use the purchased Model in consideration of purchasers' acknowledgement of and agreement to the Terms and Conditions for Taconic Models, Products and Services and the following terms of use:
- Title to these Models and biological materials derived from them remains with Taconic.
- The Models will be used for research purposes only.
- The Models will not be bred or cross-bred except to obtain embryos or fetuses required for research purposes unless additional rights have been granted in writing by Taconic.
- The Models and biological materials derived from them will not be distributed to third parties or used for commercial purposes.
- Non-profit purchasers may not use this Model and/or biological materials derived from it in sponsored research or contract research studies unless it is purchased at the for-profit price.
Pricing - USD
Murine Pathogen Free (MPF) Health Standard
1349 Female
1349-F Genotype tg/wt
| Age in Weeks | Quantity 1 - 999 |
| 6 to 12 | $772.00 |
| 13 to 21 | $821.00 |
| 22 to 29 | $950.00 |
| 30 to 38 | $1,065.00 |
| 39 to 45 | $1,185.00 |
1349-F Genotype wt/wt
| Age in Weeks | Quantity 1 - 999 |
| 6 to 12 | $313.00 |
| 13 to 21 | $381.00 |
| 22 to 29 | $554.00 |
| 30 to 38 | $742.00 |
| 39 to 45 | $890.00 |
1349-RD1-F Genotype tg/wt.
| Age in Weeks | Quantity 1 - 999 |
| 6 to 12 | $1,036.00 |
| 13 to 21 | $1,082.00 |
| 22 to 29 | $1,215.00 |
| 30 to 38 | $1,320.00 |
| 39 to 45 | $1,450.00 |
1349-RD1-F Genotype wt/wt.
| Age in Weeks | Quantity 1 - 999 |
| 6 to 12 | $467.00 |
| 13 to 21 | $531.00 |
| 22 to 29 | $709.00 |
| 30 to 38 | $894.00 |
| 39 to 45 | $1,045.00 |
1349 Male
1349-M Genotype tg/wt
| Age in Weeks | Quantity 1 - 999 |
| 6 to 12 | $772.00 |
| 13 to 21 | $821.00 |
| 22 to 29 | $950.00 |
| 30 to 38 | $1,065.00 |
| 39 to 45 | $1,185.00 |
1349-M Genotype wt/wt
| Age in Weeks | Quantity 1 - 999 |
| 6 to 12 | $313.00 |
| 13 to 21 | $381.00 |
| 22 to 29 | $554.00 |
| 30 to 38 | $742.00 |
| 39 to 45 | $890.00 |
1349-RD1-M Genotype tg/wt.
| Age in Weeks | Quantity 1 - 999 |
| 6 to 12 | $1,036.00 |
| 13 to 21 | $1,082.00 |
| 22 to 29 | $1,215.00 |
| 30 to 38 | $1,320.00 |
| 39 to 45 | $1,450.00 |
1349-RD1-M Genotype wt/wt.
| Age in Weeks | Quantity 1 - 999 |
| 6 to 12 | $467.00 |
| 13 to 21 | $531.00 |
| 22 to 29 | $709.00 |
| 30 to 38 | $894.00 |
| 39 to 45 | $1,045.00 |
Pricing - EUR
Murine Pathogen Free (MPF) Health Standard
1349 Female
1349-F Genotype tg/wt
| Age in Weeks | Quantity 1 - 999 |
| 6 to 12 | €667,00 |
| 13 to 21 | €711,00 |
| 22 to 29 | €823,00 |
| 30 to 38 | €922,00 |
| 39 to 45 | €1.027,00 |
1349-F Genotype wt/wt
| Age in Weeks | Quantity 1 - 999 |
| 6 to 12 | €270,00 |
| 13 to 21 | €330,00 |
| 22 to 29 | €478,00 |
| 30 to 38 | €641,00 |
| 39 to 45 | €773,00 |
1349-RD1-F Genotype tg/wt.
| Age in Weeks | Quantity 1 - 999 |
| 6 to 12 | €897,00 |
| 13 to 21 | €938,00 |
| 22 to 29 | €1.053,00 |
| 30 to 38 | €1.143,00 |
| 39 to 45 | €1.257,00 |
1349-RD1-F Genotype wt/wt.
| Age in Weeks | Quantity 1 - 999 |
| 6 to 12 | €405,00 |
| 13 to 21 | €460,00 |
| 22 to 29 | €615,00 |
| 30 to 38 | €774,00 |
| 39 to 45 | €905,00 |
1349 Male
1349-M Genotype tg/wt
| Age in Weeks | Quantity 1 - 999 |
| 6 to 12 | €667,00 |
| 13 to 21 | €711,00 |
| 22 to 29 | €823,00 |
| 30 to 38 | €922,00 |
| 39 to 45 | €1.027,00 |
1349-M Genotype wt/wt
| Age in Weeks | Quantity 1 - 999 |
| 6 to 12 | €270,00 |
| 13 to 21 | €330,00 |
| 22 to 29 | €478,00 |
| 30 to 38 | €641,00 |
| 39 to 45 | €773,00 |
1349-RD1-M Genotype tg/wt.
| Age in Weeks | Quantity 1 - 999 |
| 6 to 12 | €897,00 |
| 13 to 21 | €938,00 |
| 22 to 29 | €1.053,00 |
| 30 to 38 | €1.143,00 |
| 39 to 45 | €1.257,00 |
1349-RD1-M Genotype wt/wt.
| Age in Weeks | Quantity 1 - 999 |
| 6 to 12 | €405,00 |
| 13 to 21 | €460,00 |
| 22 to 29 | €615,00 |
| 30 to 38 | €774,00 |
| 39 to 45 | €905,00 |
Pricing - USD Nonprofit
Murine Pathogen Free (MPF) Health Standard
1349 Female
1349-F Genotype tg/wt
| Age in Weeks | Quantity 1 - 999 |
| 6 to 12 | $694.00 |
| 13 to 21 | $739.00 |
| 22 to 29 | $856.00 |
| 30 to 38 | $958.00 |
| 39 to 45 | $1,067.00 |
1349-F Genotype wt/wt
| Age in Weeks | Quantity 1 - 999 |
| 6 to 12 | $282.00 |
| 13 to 21 | $343.00 |
| 22 to 29 | $499.00 |
| 30 to 38 | $667.00 |
| 39 to 45 | $801.00 |
1349-RD1-F Genotype tg/wt.
| Age in Weeks | Quantity 1 - 999 |
| 6 to 12 | $933.00 |
| 13 to 21 | $974.00 |
| 22 to 29 | $1,093.00 |
| 30 to 38 | $1,189.00 |
| 39 to 45 | $1,306.00 |
1349-RD1-F Genotype wt/wt.
| Age in Weeks | Quantity 1 - 999 |
| 6 to 12 | $421.00 |
| 13 to 21 | $479.00 |
| 22 to 29 | $638.00 |
| 30 to 38 | $804.00 |
| 39 to 45 | $940.00 |
1349 Male
1349-M Genotype tg/wt
| Age in Weeks | Quantity 1 - 999 |
| 6 to 12 | $694.00 |
| 13 to 21 | $739.00 |
| 22 to 29 | $856.00 |
| 30 to 38 | $958.00 |
| 39 to 45 | $1,067.00 |
1349-M Genotype wt/wt
| Age in Weeks | Quantity 1 - 999 |
| 6 to 12 | $282.00 |
| 13 to 21 | $343.00 |
| 22 to 29 | $499.00 |
| 30 to 38 | $667.00 |
| 39 to 45 | $801.00 |
1349-RD1-M Genotype tg/wt.
| Age in Weeks | Quantity 1 - 999 |
| 6 to 12 | $933.00 |
| 13 to 21 | $974.00 |
| 22 to 29 | $1,093.00 |
| 30 to 38 | $1,189.00 |
| 39 to 45 | $1,306.00 |
1349-RD1-M Genotype wt/wt.
| Age in Weeks | Quantity 1 - 999 |
| 6 to 12 | $421.00 |
| 13 to 21 | $479.00 |
| 22 to 29 | $638.00 |
| 30 to 38 | $804.00 |
| 39 to 45 | $940.00 |
Pricing - EUR Nonprofit
Murine Pathogen Free (MPF) Health Standard
1349 Female
1349-F Genotype tg/wt
| Age in Weeks | Quantity 1 - 999 |
| 6 to 12 | €601,00 |
| 13 to 21 | €640,00 |
| 22 to 29 | €740,00 |
| 30 to 38 | €830,00 |
| 39 to 45 | €924,00 |
1349-F Genotype wt/wt
| Age in Weeks | Quantity 1 - 999 |
| 6 to 12 | €243,00 |
| 13 to 21 | €296,00 |
| 22 to 29 | €431,00 |
| 30 to 38 | €577,00 |
| 39 to 45 | €695,00 |
1349-RD1-F Genotype tg/wt.
| Age in Weeks | Quantity 1 - 999 |
| 6 to 12 | €807,00 |
| 13 to 21 | €845,00 |
| 22 to 29 | €948,00 |
| 30 to 38 | €1.029,00 |
| 39 to 45 | €1.132,00 |
1349-RD1-F Genotype wt/wt.
| Age in Weeks | Quantity 1 - 999 |
| 6 to 12 | €364,00 |
| 13 to 21 | €414,00 |
| 22 to 29 | €554,00 |
| 30 to 38 | €696,00 |
| 39 to 45 | €815,00 |
1349 Male
1349-M Genotype tg/wt
| Age in Weeks | Quantity 1 - 999 |
| 6 to 12 | €601,00 |
| 13 to 21 | €640,00 |
| 22 to 29 | €740,00 |
| 30 to 38 | €830,00 |
| 39 to 45 | €924,00 |
1349-M Genotype wt/wt
| Age in Weeks | Quantity 1 - 999 |
| 6 to 12 | €243,00 |
| 13 to 21 | €296,00 |
| 22 to 29 | €431,00 |
| 30 to 38 | €577,00 |
| 39 to 45 | €695,00 |
1349-RD1-M Genotype tg/wt.
| Age in Weeks | Quantity 1 - 999 |
| 6 to 12 | €807,00 |
| 13 to 21 | €845,00 |
| 22 to 29 | €948,00 |
| 30 to 38 | €1.029,00 |
| 39 to 45 | €1.132,00 |
1349-RD1-M Genotype wt/wt.
| Age in Weeks | Quantity 1 - 999 |
| 6 to 12 | €364,00 |
| 13 to 21 | €414,00 |
| 22 to 29 | €554,00 |
| 30 to 38 | €696,00 |
| 39 to 45 | €815,00 |
Select my Health Standard
Need help choosing the right Taconic Biosciences health standard for your research?
Use the Health Standard Selector to enter your exclusion list. The tool will tell you which health standards meet your requirements.
Get custom pricing guide
Schedule A Scientific Consultation
Speak with a PhD-level Field Application Scientist who can help you select the most appropriate model and maximize your experimental success.
