The EphB4 KinaseSwitch mouse strain was generated by Cellular Genomics Inc. using C57BL/6 ES cells. Gene targeting in ES cells was used to insert the T693A point mutation into the mouse genome. Targeted ES cells were validated and used for mouse production using standard techniques. The line was cryopreserved as heterozygote embryos. When Taconic acquired the exclusive rights to the KinaseSwitch technology from Princeton University, cryopreserved embryos were transferred to Taconic for rederivation via embryo transfer. The mouse line has been intercrossed to homozygosity and is maintained as a homozygous colony.
Animal Diet: NIH #31M Rodent Diet
Access to this model requires execution of an agreement and cryorecovery services to recover the line. Non-profit users may execute a Limited Breeding Agreement which currently carries a fee of $2,500/year. This line is offered for contract production to for-profit users. For-profit users must sign a license agreement which currently carries a fee of $5,000/year. Cryorecovery and contract production fees are additional.
Availability: This model is available for immediate cryorecovery.
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