Origin: The ApoE mouse was developed in the laboratory of Nobuya Maeda at the University of North Carolina. The model was created by targeting the Apoe gene in E14TG2a ES cells and injecting the targeted cells into C57BL/6J blastocysts. Resultant chimeras were backcrossed for ten generations (N10) and intercrossed to homozygosity. Taconic received stock in May 1998 and backcrossed one additional generation (N11). The line was derived by embryo transfer and is maintained by incrossing homozygous mice.
Genetics: Wild type for Nnt mutation
Initial Publication: Piedrahita JA, Zhang SH, Hagaman JR, Oliver PM, Maeda N. (1992) Generation of mice carrying a mutant apolipoprotein E gene inactivated by gene targeting in embryonic stem cells. Proc Natl Acad Sci USA, 89(10):4471-5.
Label License: Conditions of Use for Taconic Transgenic Models™
Taconic Transgenic Models are produced in Isolated Barrier Unit (IBU™) facilities under MPF™ conditions, and shipped in Taconic Transit Cages (TTC™).
|4 to 8||$96.80||$95.90|
|9 to 12||$104.90||$103.90|
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