| Model No. | Nomenclature | Genotype |
|---|---|---|
| 13074 | B6;129-Dll1tm1Mjo | Inquire for genotype |
Floxed Dll1 Mouse
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- Overview
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Overview
Nomenclature: B6;129-Dll1tm1Mjo
- May be used to generate constitutive or conditional knockouts of the Dll1 gene by crossing to the cre line of choice.
- Dll1 is a Notch ligand
- Useful for studies of Notch signaling, development, immune system development and function as well as autoimmune disease studies
Availability
This model is available for immediate cryorecovery.Origin
The Floxed Dll1 Mouse was developed by Katsuto Hozumi in the laboratory of Michael Owen at the Laboratory of Lymphocyte Molecular Biology, Cancer Research UK, and further developed and characterized by Rachael Brooker in the laboratory of Julian Lewis at the Vertebrate Development Laboratory, Cancer Research UK. The model was generated by targeting the Dll1 gene to generate a floxed allele in 129-derived ES cells. The targeting vector includes a loxP site inserted before exon 3 and a loxP-flanked resistance cassette after exon 4. Properly targeted ES cells were transfected with a Cre expression vector to excise the resistance cassette and injected into C57BL/6 blastocysts. Chimeric offspring were mated to C57BL/6 mice. Taconic received embryos from CRT in 2013.
Source: Sponsor: Cancer Research Technology
This model is cryopreserved and available for recovery. Models can typically be recovered and delivered to customers within 14-16 weeks after order receipt. Purchase of this model includes perpetual use rights and a deliverable of four mutant animals at the Murine Pathogen Free™ health standard along with a genotyping protocol. For models which include a recombinase gene or multiple alleles, all alleles will be provided, but individual animals may not contain all mutant alleles.
Taconic’s Colony Management experts can design a plan to grow your colony faster.
Genetics
Guides & Publications
Initial Publication:
Hozumi K, Negishi N, Suzuki D, Abe N, Sotomaru Y, Tamaoki N, Mailhos C, Ish-Horowicz D, Habu S, Owen MJ. (2004) Delta-like 1 is necessary for the generation of marginal zone B cells but not T cells in vivo. Nat Immunol. 5(6):638-44.
Applications & Therapeutic Areas
- Immunology
- Oncology & Immuno-Oncology
- Inflammation
Transit, Housing & Welfare
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- Licensing
- Pricing - USD
- Pricing - EUR
- Select my Health Standard
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Floxed Dll1 Mouse
Customers may purchase this model by signing the appropriate Terms of Sale (below) and providing a PO.
This model is sold under terms which grant perpetual use rights.
This model is sold under terms which grant perpetual use rights.
Pricing - USD
13074
| Item | Commercial | Nonprofit |
|---|---|---|
| Cryopreserved Model | $23,100.00 | $14,700.00 |
Cryopreserved models are invoiced upon shipment of recovered animals. Once orders are placed, the full purchase price will be applied if the order is canceled. For orders greater than 4 animals, please contact Taconic for options.
Fees for Taconic Transit Cages™ and freight are in addition to the price above.
Pricing - EUR
13074
| Item | Commercial | Nonprofit |
|---|---|---|
| Cryopreserved Model | €21.000,00 | €13.125,00 |
Cryopreserved models are invoiced upon shipment of recovered animals. Once orders are placed, the full purchase price will be applied if the order is canceled. For orders greater than 4 animals, please contact Taconic for options.
Fees for Taconic Transit Cages™ and freight are in addition to the price above.
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