Alzheimer's Disease Mouse Models for Drug Discovery & Therapeutic Research
Taconic offers state-of-the-art Alzheimer’s disease models that enhance our scientific understanding of disease progression and advance drug discovery efforts.
Key Features of Our Alzheimer’s Disease Mouse Models
Taconic Biosciences offers genetically engineered Alzheimer’s disease (AD) mouse models that replicate key features such as β-amyloid plaques, tau pathology, cognitive decline, and neuroinflammation. These highly translatable models are key in advancing preclinical research and drug discovery efforts. Designed for precision and reliability, models have been validated for use in therapeutic development. With ready-to-use cohorts, custom model generation capabilities including targeted transgenesis, and expert scientific support, Taconic empowers researchers to achieve breakthroughs in Alzheimer’s disease treatment. Contact us today to find the right model for your study.
View:
Select One
- Familial AD Mouse Models
- Sporadic AD Mouse Models
Familial Alzheimer's Disease Mouse Models
View a timeline of neuropathology of these murine models as well as amyloid plaque development in the APPSWE mouse brain.
Sporadic Alzheimer's Disease Mouse Models
Learn about the benefits of using sporadic AD murine models for studying the role of human APOE polymorphism neurodegenerative disorders.
Why Alzheimer’s Disease Models are Critical for Drug Discovery
Animal models are essential for understanding Alzheimer’s disease mechanisms, testing potential therapies, and bridging the gap between discovery and clinical success. Mouse models play a crucial role in replicating key features of AD, including β-amyloid accumulation, tau pathology, and neuroinflammation, allowing researchers to study disease progression and evaluate novel treatments. By providing a controlled, reproducible system to test drug efficacy and safety before human trials, these models help accelerate the development of effective therapeutics. Taconic Biosciences offers a diverse portfolio of Alzheimer’s disease mouse models, supporting researchers in their mission to combat this devastating disease.
Benefits of Taconic’s Transgenic Models for Alzheimer’s Disease
The APPSWE (Tg2576) mouse model from Taconic Biosciences is a cornerstone in Alzheimer's research and has been critical in preclinical investigations for several FDA-approved drugs, including donepezil, galantamine, and memantine.
Recent studies using Taconic mice have demonstrated the potential of M1 positive allosteric modulators (PAMs) like PQCA in combination therapies. This approach could improve cognitive function while reducing the severe side effects associated with traditional cholinesterase inhibitors.
With hallmark Alzheimer's disease phenotypes such as amyloid plaque accumulation and cognitive deficits, Taconic’s mouse models are vital tools for researchers seeking to develop next-generation treatments that address both disease progression and symptom management.
On-Demand Webinar
Improving Preclinical Neuroscience Study Design with AlzPED Data
Watch this webinar to learn more about best practices for rigorous preclinical screening and testing of candidate therapeutics for neurodegenerative diseases.
Partner with Us to Drive Alzheimer's Discoveries
Research Success Stories and Case Studies
Customer Reviews and Testimonials
"Taconic Biosciences has been an invaluable resource for the entire Alzheimer's disease (AD) research community. As an academic researcher that builds animal models of sporadic AD I cannot possibly supply the communities needs for these models but instead depend on Taconic to fulfill this role. My hope is that as new and improved models become characterized and validated that the research community at large will supply these models to Taconic to manage and distribute."
Patrick Sullivan, PhD, Associate Professor of Geriatrics at major university
"Cure Alzheimer's Fund is working closely with Taconic on our Genes to Therapies program, which supports investigations of gene variants impacting risk of Alzheimer's through funded research and the development of specialized genetically engineered mouse strains. The team at Taconic has provided excellent project management and technical support and are vital partners for the success of a complex project involving many custom strains and academic research labs.”
Scientific Poster
Alzheimer's Disease in 3D: Characterization of Plaques and Neuroinflammation with AD Mouse Models Using Innovative Tissue Clearing and Imaging Techniques
View this poster to see proof-of-concept ex vivo 3D imaging, showcasing the characterization of β-amyloid plaque distribution and densities, along with other pathological markers in ARTE10 (APP-PS1) and APPSWE (Tg2576) mouse brains across different ages.
Scientific Poster
High-throughput quantitative whole-brain 3D imaging of congophilic amyloid plaque load in a transgenic mouse model of Alzheimer’s disease
View this poster to explore a novel LSFM and deep-learning pipeline for automated whole-brain 3D mapping and quantification of congophilic and amyloid plaques, enabling high-resolution analysis of parenchymal and cerebrovascular amyloid pathology in an AD mouse model.
Frequently Asked Alzheimer's Mouse Model Questions
Learn more about using mouse models in your Alzheimer's Disease research.
These are genetically modified or induced mouse models designed to replicate key pathological features of Alzheimer’s disease (AD), such as amyloid-beta plaques, tau tangles, and cognitive decline.
Mice share genetic and biological similarities with humans, and their shorter lifespan allows for studying disease progression efficiently.
These models help researchers understand disease mechanisms, test new therapies, and evaluate the efficacy and safety of potential treatments.
Standardize age, gender, environment, diet, and test conditions to ensure reproducibility.
Yes, many strains are available as cryopreserved embryos or sperm, allowing for on-demand recovery and reducing colony maintenance costs. Cryopreservation ensures strain availability, genetic stability, and cost-effective colony management.