Nomenclature: STOCK Tg(APPSWE)2576Kha Tg(Prnp-MAPT*P301L)JNPL3Hlmc

• Carries the transgene coding for the 695-amino acid isoform of human Alzheimer β-amyloid (Aβ) protein in addition to the transgene for the human P301L mutation of the microtubule-associated protein tau gene (MAPT)
• Amyloid plaque distribution, number, morphology and density is similar between APPSWE-Tau mice and APPSWE mice
• Motor disturbances and morphology of neurofibrillary tangles (NFT) is comparable between the APPSWE-Tau and Tau mice, although older female APPSWE-Tau mice have a marked increase in limbic areas compared to Tau females
• Useful for the study of Alzheimer's Disease that address both the formation of β-amyloid plaques and NFT and to study drugs for treatment or prevention of Alzheimer's disease
• The 2469 Hemizygous / Hemizygous mice are hemizygous for the APPSWE mutation and hemizygous for the Tau mutation.
• The 2469 Wild Type / Hemizygous mice are wild type for the APP mutation and hemizygous for the Tau mutation and serve as one control for the 2469 Hemizygous / Hemizygous model.
• Pink eyed animals, associated with certain coat colors, and the Pde6brd1 retinal degeneration mutation can cause light sensitivity and/or blindness in some animals. This may impact the results of behavioral testing. Upon request, animals can be screened for eye color, coat color, and/or rd1 homozygosity for an additional fee.
• Rd1 tested mice (2469-RD1-F and 2469-RD1-M) are wild type or heterozygous for the Pde6b^rd1 mutation. Genotype shown in the table above refers to the APPSWE and Tau transgenes.

Origin