• Alzheimers Disease
• Genetically Humanized
• Neuroscience
• Psychiatric Disorders

• Premature mortality is an expected phenotype of this line, with mortality of 20% anticipated, particularly in males. Please take this into consideration when deciding upon order size to retain the needed experimental group size
• Shipping Guidelines: Taconic recommends that customers purchase mice between 10 and 12 weeks of age. Due to a phenotype of sudden death at young ages, Taconic cannot guarantee shipment of mice 9 weeks of age or younger.
• Between 7 to 12 weeks of age males become aggressive and begin to fight. Male APPSWE mice are shipped in divided Taconic Transit Cages™ with one animal per section. We highly recommend housing APPSWE male mice one per cage.
• Barbering is common in this strain, particularly in older females, and is usually caused by over-grooming from a cagemate. Barbered animals display alopecia (hair loss) around the eyes, nose, head or back, which can range from mild hair loss to large areas of missing hair. Skin is typically not affected, and no medical treatment is indicated for hair loss caused by barbering. Because of the high incidence of barbering in this strain, animals with mild to moderate barbering may be included in shipments.
• APPSWE mice may develop circling behavior.
  

Hemizygous male 1349 mice are packed one per TTC section, with a maximum of 4 mice per TTC. Wild type 1349 mice are packed as cagemates, one cage per Taconic Transit Cage (TTC).  Customers should take care recombining 1349 males from different TTCs or TTC sections into the same cage at or after unpacking.

NIH #31M Rodent Diet