Model No. | Nomenclature | Genotype |
---|---|---|
1547-F | B6.129P2-Apoetm1(APOE*2)Mae N9 | hu/hu |
1547-M | B6.129P2-Apoetm1(APOE*2)Mae N9 | hu/hu |
Model No. | Nomenclature | Genotype |
---|---|---|
1547-F | B6.129P2-Apoetm1(APOE*2)Mae N9 | hu/hu |
1547-M | B6.129P2-Apoetm1(APOE*2)Mae N9 | hu/hu |
Nomenclature: B6.129P2-Apoetm1(APOE*2)Mae N9
Origin
The APOE2 targeted replacement mouse was developed in the laboratory of Nobuya Maeda at the University of North Carolina. The model was created by targeting the murine Apoe gene for replacement with the human APOE2 allele in E14TG2a ES cells and injecting the targeted cells into blastocysts. Resultant chimeras were backcrossed to C57BL/6 for seven generations (N7). Taconic received stock in 2000. The mice were backcrossed two additional times (N9) and embryo transfer derived. Additional backcrossing to C57BL/6NTac was completed, and the line is now congenic on this B6 substrain. The colony is maintained through incrossing of homozygotes.
Initial Publication:
Sullivan PM, Mezdour H, Quarfordt SH, Maeda N. (1998) Type III hyperlipoproteinemia and spontaneous atherosclerosis in mice resulting from gene replacement of mouse apoe with human APOE*2. J Clin Invest, 102(1):130-5.
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Packing Practices
Taconic standard practice is to recombine animals of different home cages and/or ages from a single model and sex during packing, except in specific cases where Taconic's animal welfare policy prohibits recombination due to aggression or other concerns. When an order is fulfilled with animals from more than one week of birth, this standard practice results in animals from a range of birth weeks packed together in a single TTC. When an order is fulfilled with animals from genotyped models, this standard practice results in animals from different home cages packed together in a single TTC.
Customers who wish to keep animals from different weeks of birth separated should place orders with the special instruction "Divide and label by age." Note that this special request can result in increased costs for additional Taconic Transit Cages, dividers and/or freight charges.
Taconic discourages other types of custom packing requests as they can have a negative impact on animal welfare. Learn more.
Conditions of Use for Taconic Transgenic Models™
Taconic Transgenic Models™ (Models) are produced and distributed under rights to patents and intellectual property licensed from various institutions. Taconic sells the Models to purchasers, grants to each purchaser a right under Taconic's rights in such licensed patents and intellectual property to use the purchased Model in consideration of purchasers' acknowledgement of and agreement to the Terms and Conditions for Taconic Models, Products and Services and the following terms of use:
Age in Weeks | Quantity 1 - 999 |
3 to 12 | $510.00 |
Age in Weeks | Quantity 1 - 999 |
3 to 12 | $510.00 |
Age in Weeks | Quantity 1 - 999 |
3 to 12 | €442,00 |
Age in Weeks | Quantity 1 - 999 |
3 to 12 | €442,00 |
Age in Weeks | Quantity 1 - 999 |
3 to 12 | $458.00 |
Age in Weeks | Quantity 1 - 999 |
3 to 12 | $458.00 |
Age in Weeks | Quantity 1 - 999 |
3 to 12 | €397,00 |
Age in Weeks | Quantity 1 - 999 |
3 to 12 | €397,00 |
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