| Model No. | Nomenclature | Genotype |
|---|---|---|
| 9179 | C57BL/6-Abcc2tm1(ABCC2)Arte | Inquire for genotype |
Humanized MRP2 Mouse
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Overview
Nomenclature: C57BL/6-Abcc2tm1(ABCC2)Arte
- This targeted mutation strain carries a replacement of the mouse Abcc2 gene which encodes for the multidrug resistance protein (MRP2) with the corresponding human orthologous gene.
- Useful to study the role of human MRP2 in drug bioavailability.
Origin
The Humanized MRP2 Mouse was developed by Taconic in collaboration with CXR Biosciences. It was created through a targeted replacement of mouse Mrp2 Exon 2 with a cDNA construct containing human MRP2 Exons 2-32 in C57BL/6NTac-derived ES cells. This leads to the expression of a fusion protein of amino acids encoded by mouse Exons 1 and human Exons 2 to 32 driven by the mouse Mrp2 promoter, so that the potential mouse leader sequence encoded by Exon 1 is retained. Targeted ES cells were injected into BALB/cJBomTac blastocysts and the resultant chimeras were backcrossed to a Flpe deleter strain on C57BL/6J to eliminate the selection marker. Taconic received stock in 2009, and the line was embryo transfer derived. The colony was maintained by mating homozygotes.
This model is cryopreserved and available for recovery. Models can typically be recovered and delivered to customers within 14-16 weeks after order receipt. Purchase of this model includes perpetual use rights and a deliverable of four mutant animals at the Murine Pathogen Free™ health standard along with a genotyping protocol. For models which include a recombinase gene or multiple alleles, all alleles will be provided, but individual animals may not contain all mutant alleles.
Taconic’s Colony Management experts can design a plan to grow your colony faster.
Genetics
Guides & Publications
Initial Publication:
Scheer N, Balimane P, Hayward MD, Buechel S, Kauselmann G, Wolf CR. Generation and Characterization of a Novel MRP2 Humanized Mouse Line. Drug Metab Dispos. 2012 Aug 23.
Additional Publications:
Wen X, Buckley B, McCandlish E, Goedken MJ, Syed S, Pelis R, Manautou JE, Aleksunes LM. Transgenic expression of the human MRP2 transporter reduces cisplatin accumulation and nephrotoxicity in Mrp2-null mice. Am J Pathol. 2014 184(5):1299-308.
Applications & Therapeutic Areas
- ADMET
Transit, Housing & Welfare
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Diet
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- Pricing - USD
- Pricing - EUR
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Humanized MRP2 Mouse
Customers may purchase this model by signing the appropriate Terms of Sale (below) and providing a PO.
This model is sold under terms which grant perpetual use rights.
This model is sold under terms which grant perpetual use rights.
Pricing - USD
9179
| Item | Commercial | Nonprofit |
|---|---|---|
| Cryopreserved Model | $34,650.00 | $23,100.00 |
Cryopreserved models are invoiced upon shipment of recovered animals. Once orders are placed, the full purchase price will be applied if the order is canceled. For orders greater than 4 animals, please contact Taconic for options.
Fees for Taconic Transit Cages™ and freight are in addition to the price above.
Pricing - EUR
9179
| Item | Commercial | Nonprofit |
|---|---|---|
| Cryopreserved Model | €26.250,00 | €19.425,00 |
Cryopreserved models are invoiced upon shipment of recovered animals. Once orders are placed, the full purchase price will be applied if the order is canceled. For orders greater than 4 animals, please contact Taconic for options.
Fees for Taconic Transit Cages™ and freight are in addition to the price above.
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