| Model No. | Nomenclature | Genotype |
|---|---|---|
| 12666 | B6.129X1-Klrd1tm1.1lll | Inquire for genotype |
Klrd1 - Model 12666 - KO
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Overview
Nomenclature: B6.129X1-Klrd1tm1.1lll
- The targeting vector has been generated using 129 DNA and transfected into 129 ES cell line.
- Klrd1 exon 3 has been disrupted and exon 4 removed by the neomycin resistance cassette, which is flanked by loxP sites.
- The neomycin resistance gene has been deleted by transient transfection of Cre in targeted ES cells.
- Chimeric mice were produced and germ line transmission achieved.
- The constitutive KO line has been subsequently backcrossed to C57BL/6 animals for 9 generations.
- Deletion of parts of exon 3 and entire exon 4 should result in loss of function of the Klrd1 gene by deleting a dimerization and the C-type lectin-like domains.
- The remaining recombination sites are located in intron regions of the genome.
- See M.T. Orr et al, PLoS ONE 5, e15184, 2010, for further details.
Availability
Cryopreserved at TaconicSource: DNAX
This model is cryopreserved and available for recovery. Models can typically be recovered and delivered to customers within 14-16 weeks after order receipt. Purchase of this model includes perpetual use rights and a deliverable of four mutant animals at the Murine Pathogen Free™ health standard along with a genotyping protocol. For models which include a recombinase gene or multiple alleles, all alleles will be provided, but individual animals may not contain all mutant alleles.
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Transit, Housing & Welfare
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Klrd1 - Model 12666 - KO
Customers may purchase this model by signing the appropriate Terms of Sale (below) and providing a PO.
The GEM Collection Commercial and Academic Terms of Sale grant perpetual use rights.
| Item | Commercial | Nonprofit |
| Cryopreserved Model | $32,500 | $5,500 |
| Item | Commercial | Nonprofit |
| Cryopreserved Model | €29.500 | €5.005 |
Cryopreserved models are invoiced upon shipment of recovered animals. Once orders are placed, the full purchase price will be applied if the order is canceled. For orders greater than 4 animals, please contact Taconic for options.
Fees for Taconic Transit Cages™ and freight are in addition to the price above.
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