| Model No. | Nomenclature | Genotype |
|---|---|---|
| 10014 | C57BL/6-Lnpeptm1.1(H464Y_H468Y)Mrl | Inquire for genotype |
Lnpep - Model 10014 - PM
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Overview
Nomenclature: C57BL/6-Lnpeptm1.1(H464Y_H468Y)Mrl
- The targeting vector has been generated using C57BL/6J DNA and transfected into TaconicArtemis C57BL/6NTac ES cell line.
- The Lnpep exon 1 contains the translation initiation codon.
- The H464Y and H468Y point mutations have been introduced into Lnpep exon 6 (TKIIAHELAHQWFGN to TKIIAYELAYQWFGN)
- A positive selection marker (Puromycin resistance) has been flanked by F3 sites and introduced into intron 6
- The constitutive PM allele has been generated after Flp-mediated recombination by crossing chimeras to a Flp-Deleter on a C57BL/6 background.
- The constitutive PM line has been derived using C57BL/6NTac animals and the Flp-transgene was removed by segregation.
- The remaining FRT recombination site will be located in a non-conserved region of the genome.
- Datamining and Design performed in 2009.
Availability
Cryopreserved at TaconicSource: Merck Research Laboratories
This model is cryopreserved and available for recovery. Models can typically be recovered and delivered to customers within 14-16 weeks after order receipt. Purchase of this model includes perpetual use rights and a deliverable of four mutant animals at the Murine Pathogen Free™ health standard along with a genotyping protocol. For models which include a recombinase gene or multiple alleles, all alleles will be provided, but individual animals may not contain all mutant alleles.
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Genetics
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Transit, Housing & Welfare
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Lnpep - Model 10014 - PM
Customers may purchase this model by signing the appropriate Terms of Sale (below) and providing a PO.
The GEM Collection Commercial and Academic/Non-Profit Terms of Sale grant perpetual use rights.
| Item | Commercial | Nonprofit |
| Cryopreserved Model | $32,500 | $5,500 |
| Item | Commercial | Nonprofit |
| Cryopreserved Model | €29.500 | €5.005 |
Cryopreserved models are invoiced upon shipment of recovered animals. Once orders are placed, the full purchase price will be applied if the order is canceled. For orders greater than 4 animals, please contact Taconic for options.
Fees for Taconic Transit Cages™ and freight are in addition to the price above.
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