| Model No. | Nomenclature | Genotype |
|---|---|---|
| 21618 | C57BL/6-Piezo2tm1.1Tac | Inquire for genotype |
Piezo2 Conditional KI-PM Mouse
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Overview
Nomenclature: C57BL/6-Piezo2tm1.1Tac
- The model carries a conditional knock-in point mutation (cKI-PM) in the Piezo 2 (piezo-type mechanosensitive ion channel component 2).
- In absence of Cre, the model is expected to express the wildtype Piezo 2 (Fam38b) allele.
- Upon crossbreeding with a Cre model, the constitutive KI-PM allele may be obtained, facilitated by deletion of the wildtype exon 54 and expression of the mutated Piezo 2 ED2799D protein.
- This model might be useful for the study of Distal arthrogryposis (DA) disease progression and understanding.
Availability
Cryopreserved at TaconicOrigin
The Piezo 2 mouse was developed at Taconic Biosciences on behalf of Scripps Health in 2012. The model was generated using BAC clones from the C57BL/6J RPCIB-731 BAC library and was transfected into the Taconic C57BL/6NTac ES cell line. Homologous recombinant clones were isolated using double positive (NeoR and PuroR) selection. The conditional KI-PM allele was obtained after Flp-mediated removal of the selection markers. Taconic received donor animals from Scripps in 2023 and the model is stored as homozygous sperm.
Source: Taconic Biosciences
Genetics
Guides & Publications
Initial Publication:
Shang Ma, Adrienne E. Dubin, Luis O. Romero, Meaghan Loud, Alexandra Salazar, Yu Wang, Alex T. Chesler, Katherine Wilkinson, Valeria Vásquez, Kara L. Marshall, Ardem Patapoutian. BioRxiv. (2022) Excessive Mechanotransduction in Sensory Neurons Causes Joint Contractures in a Mouse Model of Arthrogryposis. doi: https://doi.org/10.1101/2022.06.07.495164 [In revision]
Transit, Housing & Welfare
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Licensing
To purchase this EZcohort model, sign the Terms of Sale (choose from the list below) and email it directly to legal@taconic.com:
This model is sold under terms which grant perpetual use rights.
This model is sold under terms which grant perpetual use rights.
Pricing - USD
21618
| Item | Commercial | Nonprofit |
|---|---|---|
| Cryopreserved Model | $23,100.00 | $17,325.00 |
Cryopreserved models are invoiced upon shipment of recovered animals. Once orders are placed, the full purchase price will be applied if the order is canceled. For orders greater than 4 animals, please contact Taconic for options.
Fees for Taconic Transit Cages™ and freight are in addition to the price above.
Pricing - EUR
21618
| Item | Commercial | Nonprofit |
|---|---|---|
| Cryopreserved Model | €21.000,00 | €15.855,00 |
Cryopreserved models are invoiced upon shipment of recovered animals. Once orders are placed, the full purchase price will be applied if the order is canceled. For orders greater than 4 animals, please contact Taconic for options.
Fees for Taconic Transit Cages™ and freight are in addition to the price above.
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