Model No. | Nomenclature | Genotype |
---|---|---|
4094 | B10.A-Rag2tm1Fwa H2-T18a Tg (Tcra5CC7,Tcrb5CC7)lwep | Inquire for genotype |
Model No. | Nomenclature | Genotype |
---|---|---|
4094 | B10.A-Rag2tm1Fwa H2-T18a Tg (Tcra5CC7,Tcrb5CC7)lwep | Inquire for genotype |
Nomenclature: B10.A-Rag2tm1Fwa H2-T18a Tg (Tcra5CC7,Tcrb5CC7)lwep
The Rag2 Knockout/Transgenic Cyt5CC7 T Cell Receptor line is homozygous for a transgene that encodes a T cell receptor that is specific for a pigeon cytochrome c peptide, amino acids 81-104, presented by the MHC class II molecule I-Ea/k. It is also deficient in the Rag2 gene (recombinase activating gene 2) and therefore does not develop endogenous mature T or B cells. Most of the T cells in the periphery are CD4+ but there also is a tiny fraction of CD8+ T cells expressing the transgene. The depletion of endogenous T and B cells causes a proportional enrichment of NK cells in the spleen. These mice are useful for in vitro studies of CD4+ T cell differentiation into TH1 and TH2 populations and as a source of donor cells for adoptive transfer into B10.A mice for in vivo studies of inflammation and tolerance. Applications include studies of inflammation, tolerance, and T cell development.
Origin
This model is cryopreserved and available for recovery. Models can typically be recovered and delivered to customers within 14-16 weeks after order receipt. Purchase of this model includes perpetual use rights and a deliverable of four mutant animals at the Murine Pathogen Free™ health standard along with a genotyping protocol. For models which include a recombinase gene or multiple alleles, all alleles will be provided, but individual animals may not contain all mutant alleles.
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Initial Publication: Seder RA, Paul WE, Davis MM, Fazekas de St Groth B; The presence of interleukin 4 during in vitro priming determines the lymphokine-producing potential of CD4+ T cells from T cell receptor transgenic mice.; J Exp Med 1992 Oct 1;176(4):1091-1098
Shinkai, Y, Rathbun, G, Lam, KP, Oltz, EM, Stewart, V, Mendelsohn, M, Charron, J, Datta, M, Young, F, Stall, AM, and Alt, FW. (1992) RAG-2-Deficient Mice Lack Mature Lymphocytes Owing to Inability to Initiate V(D)J Rearrangement, Cell, 68: 855-867.
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Item | Commercial | Nonprofit |
---|---|---|
Cryopreserved Model | $29,400.00 | $21,000.00 |
Cryopreserved models are invoiced upon shipment of recovered animals. Once orders are placed, the full purchase price will be applied if the order is canceled. For orders greater than 4 animals, please contact Taconic for options.
Fees for Taconic Transit Cages™ and freight are in addition to the price above.
Item | Commercial | Nonprofit |
---|---|---|
Cryopreserved Model | €26.250,00 | €19.425,00 |
Cryopreserved models are invoiced upon shipment of recovered animals. Once orders are placed, the full purchase price will be applied if the order is canceled. For orders greater than 4 animals, please contact Taconic for options.
Fees for Taconic Transit Cages™ and freight are in addition to the price above.
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