Tyrobp - Model 12665 - KO

  • Cryopreserved
  • Mouse
  • Not available for direct purchase by CRO
  • GEM Collection
Model No.NomenclatureGenotype
12665B6.129P2-Tyrobptm1lll Inquire for genotype
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Overview

Nomenclature: B6.129P2-Tyrobptm1lll

  • The targeting vector has been generated using 129Sv DNA and transfected into 129Sv ES cell line.
  • Tyrobp exons 3 and 4 were removed by the neomycin resistance cassette, which is flanked by loxP sites.
  • The neomycin resistance gene has been deleted by transient transfection of Cre in targeted ES cells.
  • Chimeric mice were produced and germline transmission achieved.
  • Deletion of exons 3 and 4 should result in loss of function of the Tyrobp gene by deleting the transmembrane region and part of the cytoplasmic region.
  • The remaining recombination sites are located in intron regions of the genome.
  • See A.B.H. Bakker et al, Immunity 13, 345-353, 2000, for further details.

Availability

Cryopreserved at Taconic

Source: DNAX

This model is cryopreserved and available for recovery. Models can typically be recovered and delivered to customers within 14-16 weeks after order receipt. Purchase of this model includes perpetual use rights and a deliverable of four mutant animals at the Murine Pathogen Free™ health standard along with a genotyping protocol. For models which include a recombinase gene or multiple alleles, all alleles will be provided, but individual animals may not contain all mutant alleles.

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Genetics

Species:Mouse
Strain Type:Inbred
Allele Type:Constitutive Knockout
Genetic Background:C57BL/6
Gene Family: Kinase
Gene Symbol: Tyrobp
Gene Accession Number: NM_011662
Gene Name:  TYRO protein tyrosine kinase binding protein

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Tyrobp - Model 12665 - KO

Customers may purchase this model by signing the appropriate Terms of Sale (below) and providing a PO.

The GEM Collection Commercial and Academic Terms of Sale grant perpetual use rights.

    ItemCommercialNonprofit
    Cryopreserved Model$32,500$5,500
      ItemCommercialNonprofit
      Cryopreserved Model€29.500€5.005

       

      Cryopreserved models are invoiced upon shipment of recovered animals. Once orders are placed, the full purchase price will be applied if the order is canceled. For orders greater than 4 animals, please contact Taconic for options.

      Fees for Taconic Transit Cages™ and freight are in addition to the price above.

       

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