Taconic Biosciences' Dr. Philip Dubé penned this article in Biocompare, specifically about the importance of genetic background in mouse models:
"The modern laboratory mouse is the result of over a century of careful breeding and selection for traits desirable in research. This effort has created hundreds of mouse strains with defined genetic backgrounds, each with unique characteristics such as coat color, behavior, metabolism, fecundity, immune function, and other physiological traits. As a result, certain strains may be suited for particular applications, while others may be inappropriate. This fact is well known to mouse geneticists, but is often underappreciated in the wider research community."
Read the complete article at: Biocompare.com
"The modern laboratory mouse is the result of over a century of careful breeding and selection for traits desirable in research. This effort has created hundreds of mouse strains with defined genetic backgrounds, each with unique characteristics such as coat color, behavior, metabolism, fecundity, immune function, and other physiological traits. As a result, certain strains may be suited for particular applications, while others may be inappropriate. This fact is well known to mouse geneticists, but is often underappreciated in the wider research community."