Note: This event is for Fred Hutch employees only. Please join us at one of our other upcoming events.
February 24, 2025 | Fred Hutch Cancer Center, B1-072/074/076 Suites | 100 Fairview Ave N, Seattle, WA 98109 | 11:30 AM - 1:30 PM PT
From Engraftment to Evaluation: Humanized NOG Models for Oncology & Immuno-oncology Studies
We invite you to join this presentation on the development of animal models capable of mimicking human immune responses when studying immuno-oncology and developing novel therapeutics. Significant advances in immunology modeling have been made utilizing super immunodeficient mice reconstituted with human hematopoietic stem cells (HSCs), which are able to stably differentiate and repopulate human immune cells sufficient to study many aspects of anti-tumor immune responses. This presentation will focus on the current state of immune system engraftment, the next generation models that diversify the mechanistic functionality of immune engraftment, and recent advances in modeling human immunity in immuno-oncology applications.
Key Information:
- When: Monday, February 24th
- What: Lunch & Learn Presentation: "From Engraftment to Evaluation: Humanized NOG Models for Oncology & Immuno-oncology Studies"
- Presented by: Jessica Ramadhin, PhD
- Time: 11:30-1:30 pm Pacific Time
- Where: Fred Hutch Cancer Center, B1-072/074/076 Suites | Thomas Building, 1
100 Fairview Ave N, Seattle, WA 98109
Presenter
Jessica Ramadhin, PhD 
Field Applications Scientist
Taconic Biosciences
Dr. Jessica Ramadhin received her B.A. in Biological Sciences from Cornell University and earned her Ph.D. in Infectious Diseases from the University of Georgia. During her graduate studies, she tested two anti-inflammatory compounds as therapeutics for obesity and metabolic syndrome. She then completed her postdoctoral training in the Department of Gastroenterology at Cedars-Sinai Medical Center, where she examined how myeloid-specific knockout of the glycolytic enzyme hexokinase 2 impacted rodent models of obesity, colitis, and infection. Jessica has worked with animal models for many years and has a wide range of in vivo experience related to infectious diseases, immunology, metabolism, and the gut microbiome.