Bmx-CreERT2 Mouse

Bmx-CreERT2 Random Transgenic Mouse Model
  • Cryopreserved
  • Mouse
  • Male Only
  • Not available for direct purchase by CRO
Model No.NomenclatureGenotype
14081C57BL/6J-Tg(Bmx-cre/ERT2)1RhaInquire for genotype
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Overview

Nomenclature: C57BL/6J-Tg(Bmx-cre/ERT2)1Rha

  • An inducible cre deleter under the control of the BMX non-receptor tyrosine kinase promoter.
  • Cre recombination is inducible via administration of tamoxifen.
  • Useful for study of angiogenesis, atherosclerosis and neovascularization.
  • Non-induced Bmx-CreERT2 mice demonstrate no Cre recombinase activity, while tamoxifen-induced Bmx-CreERT2 mice demonstrate high levels of recombinase-mediated gene deletion in endothelial cells (95%+).

Origin

The Bmx-Cre-ERT2 mouse was developed in the laboratory of Ralf Adams at the London Research Institute. The model was generated by microinjecting a transgene containing a genomic Bmx promoter fragment fused to a CreERT2 cDNA into B6xCBA F1 zygotes. Founder lines were backcrossed to C57BL/6 for at least five generations. Taconic received embryos from CRT in 2015.

Source: Cancer Research Technology (CRT)

This model is cryopreserved and available for recovery. Models can typically be recovered and delivered to customers within 12 weeks after order receipt. Purchase of this model includes perpetual use rights and a deliverable of four mutant animals at the Murine Pathogen Free™ health standard along with a genotyping protocol. For models which include a recombinase gene or multiple alleles, all alleles will be provided, but individual animals may not contain all mutant alleles.

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Genetics

Species:Mouse
Strain Type:Congenic
Allele Type:Recombinase-expressing;Random Transgenic
Genetic Background:C57BL/6

Guides & Publications

Applications & Therapeutic Areas

  • Oncology & Immuno-Oncology
  • Recombinase-mediated Gene Deletion

Transit, Housing & Welfare

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Bmx-CreERT2 Mouse

Customers may purchase this model by signing the appropriate Terms of Sale (below) and providing a PO.
This model is sold under terms which grant perpetual use rights.

Pricing - USD

14081

ItemCommercialNonprofit
Cryopreserved Model$21,000.00$13,000.00

Cryopreserved models are invoiced upon shipment of recovered animals. Once orders are placed, the full purchase price will be applied if the order is canceled. For orders greater than 4 animals, please contact Taconic for options.

Fees for Taconic Transit Cages™ and freight are in addition to the price above.

Pricing - EUR

14081

ItemCommercialNonprofit
Cryopreserved Model€21.000,00€13.000,00

Cryopreserved models are invoiced upon shipment of recovered animals. Once orders are placed, the full purchase price will be applied if the order is canceled. For orders greater than 4 animals, please contact Taconic for options.

Fees for Taconic Transit Cages™ and freight are in addition to the price above.

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Get your Taconic Biosciences 2024 Pricing Guide today. Personalized, customizable, links to up-to-date health reports, and additional information on Taconic's products and services.