| Model No. | Nomenclature | Genotype |
|---|---|---|
| 13073 | C57BL/6-Tg(Cdh5-cre/ERT2)1Rha |
Cdh5(PAC)-CreERT2 Mouse
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- Overview
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Overview
Nomenclature: C57BL/6-Tg(Cdh5-cre/ERT2)1Rha
- An inducible cre deleter under the control of the vascular endothelial cadherin (Cdh5(PAC)) promoter
- Cre recombination is inducible via administration of tamoxifen
- Useful for study of angiogenesis, atherosclerosis and neovascularization
- Non-induced Cdh5(PAC)-CreERT2 mice demonstrate no Cre recombinase activity, while tamoxifen-induced Cdh5(PAC)-CreERT2 mice demonstrate high levels of recombinase-mediated gene deletion in vascular endothelial cells (95%+).
Availability
Limited quantities of breeders are available for purchase after execution of a license.Ordering Note: Animals ordered at 4 weeks of age require rapid genotyping and a $40.00 per mouse charge will be added.
Origin
The Cdh5(PAC)-CreERT2 Mouse was developed in the laboratory of Ralf Adams at the London Research Institute. The model was generated by microinjecting a transgene containing a genomic Cdh5(PAC) promoter fragment fused to a CreERT2 cDNA into C57BL/6 zygotes. Founder lines were backcrossed to C57BL/6 for at least five generations. Taconic received embryos from CRT in 2013.
Source: Cancer Research Technology
Genetics
Guides & Publications
Initial Publication:
Sörensen I, Adams RH, Gossler A. (2009) DLL1-mediated Notch activation regulates endothelial identity in mouse fetal arteries. Blood. 113(22):5680-8.
Applications & Therapeutic Areas
- Cardiovascular Disease
- Oncology & Immuno-Oncology
- Recombinase-mediated Gene Deletion
Transit, Housing & Welfare
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Diet
- Licensing
- Pricing - USD
- Pricing - EUR
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Licensing
To purchase this model, sign the Terms of Sale (choose from the list below) and email it directly to legal@taconic.com:
This model is sold under terms which grant perpetual use rights. Live mice may be purchased once the Terms of Sale have been executed and a form of payment provided for the license fee.
This model is sold under terms which grant perpetual use rights. Live mice may be purchased once the Terms of Sale have been executed and a form of payment provided for the license fee.
Pricing - USD
Murine Pathogen Free™ (MPF™)
13073 - Female
13073 - F Genotype tg/wt
| Age in Weeks | Quantity 1-999 |
| 4 to 10 | $371.00 |
13073 - Male
13073 - M Genotype tg/wt
| Age in Weeks | Quantity 1-999 |
| 4 to 10 | $371.00 |
13073
| Item | Commercial | Nonprofit |
|---|---|---|
| License Fee | $31,500.00 | $9,450.00 |
Note: A fee-bearing agreement is required prior to purchase of this line.
Pricing - EUR
Murine Pathogen Free™ (MPF™)
13073 - Female
13073 - F Genotype tg/wt
| Age in Weeks | Quantity 1-999 |
| 4 to 10 | €340.00 |
13073 - Male
13073 - M Genotype tg/wt
| Age in Weeks | Quantity 1-999 |
| 4 to 10 | €340.00 |
13073
| Item | Commercial | Nonprofit |
|---|---|---|
| License Fee | €28,350.00 | €8,400.00 |
Note: A fee-bearing agreement is required prior to purchase of this line.
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