| Model No. | Nomenclature | Genotype |
|---|---|---|
| 10053 | C57BL/6-Dpp4tm1.1Mrl | Inquire for genotype |
Dpp4 - Model 10053 - cKO
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Overview
Nomenclature: C57BL/6-Dpp4tm1.1Mrl
- The targeting vector has been generated using C57BL/6J DNA and transfected into C57BL/6NTac ES cell line.
- Dpp4 exon 1 contains the translation initiation codon.
- Exon 20 has been flanked by loxP sites.
- The conditional KO allele has been generated after Cre-mediated recombination by crossing chimeras to a Cre-Deleter on a C57BL/6 background.
- The conditional KO line has been subsequently backcrossed to C57BL/6NTac animals for at least 2 generations and the Cre-transgene was removed by segregation.
- Deletion of exon 20 should result in loss of function of the Dpp4 gene by deleting the peptidase S9 domain.
- The remaining recombination sites are located in intron regions of the genome.
- The constitutive KO allele is also available as line 11085.
- Data mining and Design performed in 2006.
Availability
Cryopreserved at TaconicSource: Mouse Clinical Institute (MCI)
This model is cryopreserved and available for recovery. Models can typically be recovered and delivered to customers within 12 weeks after order receipt. Purchase of this model includes perpetual use rights and a deliverable of four mutant animals at the Murine Pathogen Free™ health standard along with a genotyping protocol. For models which include a recombinase gene or multiple alleles, all alleles will be provided, but individual animals may not contain all mutant alleles.
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Genetics
Dpp4 WT, Size=87159 bps
10053 Dpp4 cKO, Size=10360 bps
Dpp4 KO, Size=10000 bps
Guides & Publications
Transit, Housing & Welfare
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Dpp4 - Model 10053 - cKO
Customers may purchase this model by signing the appropriate Terms of Sale (below) and providing a PO.
The GEM Collection Commercial and Academic/Non-Profit Terms of Sale grant perpetual use rights.
| Item | Commercial | Nonprofit |
| Cryopreserved Model | $32,500 | $5,500 |
| Item | Commercial | Nonprofit |
| Cryopreserved Model | €29.500 | €5.005 |
Cryopreserved models are invoiced upon shipment of recovered animals. Once orders are placed, the full purchase price will be applied if the order is canceled. For orders greater than 4 animals, please contact Taconic for options.
Fees for Taconic Transit Cages™ and freight are in addition to the price above.
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