| Model No. | Nomenclature | Genotype |
|---|---|---|
| 10053 | C57BL/6-Dpp4tm1.1Mrl | Inquire for genotype |
Dpp4 - Model 10053 - cKO
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Overview
Nomenclature: C57BL/6-Dpp4tm1.1Mrl
- The targeting vector has been generated using C57BL/6J DNA and transfected into C57BL/6NTac ES cell line.
- Dpp4 exon 1 contains the translation initiation codon.
- Exon 20 has been flanked by loxP sites.
- The conditional KO allele has been generated after Cre-mediated recombination by crossing chimeras to a Cre-Deleter on a C57BL/6 background.
- The conditional KO line has been subsequently backcrossed to C57BL/6NTac animals for at least 2 generations and the Cre-transgene was removed by segregation.
- Deletion of exon 20 should result in loss of function of the Dpp4 gene by deleting the peptidase S9 domain.
- The remaining recombination sites are located in intron regions of the genome.
- The constitutive KO allele is also available as line 11085.
- Data mining and Design performed in 2006.
Availability
Cryopreserved at TaconicSource: Mouse Clinical Institute (MCI)
This model is cryopreserved and available for recovery. Models can typically be recovered and delivered to customers within 14-16 weeks after order receipt. Purchase of this model includes perpetual use rights and a deliverable of four mutant animals at the Murine Pathogen Free™ health standard along with a genotyping protocol. For models which include a recombinase gene or multiple alleles, all alleles will be provided, but individual animals may not contain all mutant alleles.
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Genetics
Dpp4 WT, Size=87159 bps
10053 Dpp4 cKO, Size=10360 bps
Dpp4 KO, Size=10000 bps
Guides & Publications
Transit, Housing & Welfare
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Dpp4 - Model 10053 - cKO
Customers may purchase this model by signing the appropriate Terms of Sale (below) and providing a PO.
The GEM Collection Commercial and Academic Terms of Sale grant perpetual use rights.
| Item | Commercial | Nonprofit |
| Cryopreserved Model | $32,500 | $5,500 |
| Item | Commercial | Nonprofit |
| Cryopreserved Model | €29.500 | €5.005 |
Cryopreserved models are invoiced upon shipment of recovered animals. Once orders are placed, the full purchase price will be applied if the order is canceled. For orders greater than 4 animals, please contact Taconic for options.
Fees for Taconic Transit Cages™ and freight are in addition to the price above.
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