| Model No. | Nomenclature | Genotype |
|---|---|---|
| 14096 | B6;129-Tnfrsf25tm1Mjo | Inquire for genotype |
DR3 Knockout Mouse
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Overview
Nomenclature: B6;129-Tnfrsf25tm1Mjo
- Knockout of the tumor necrosis factor receptor superfamily, member 25 Tnfrsf25 (also known as Dr3) gene
- Dr3 mediates regulation of the cell division cycle.
- Negative selection and anti-CD3-induced apoptosis are significantly impaired in Dr3-null mice.
Origin
The Dr3 knockout mouse was developed in the laboratory of Eddie Wang at the Imperial Cancer Research Fund, Lincoln's Inn Fields, London. A DR3 targeting vector, replacing the entire DR3 coding region with a loxP flanked resistance cassette, was transfected into GK129 ES cells. Correctly targeted ES cells were injected into C57BL/6 blastocysts. Chimeric offspring were mated to C57BL/6 mice to yield mice heterozygous for the mutant allele. Heterozygous mice were interbred to generate homozygous Dr3-/- mice. Taconic received embryos from CRT in 2015.
Source: Cancer Research Technology (CRT)
This model is cryopreserved and available for recovery. Models can typically be recovered and delivered to customers within 12 weeks after order receipt. Purchase of this model includes perpetual use rights and a deliverable of four mutant animals at the Murine Pathogen Free™ health standard along with a genotyping protocol. For models which include a recombinase gene or multiple alleles, all alleles will be provided, but individual animals may not contain all mutant alleles.
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Genetics
Guides & Publications
Initial Publication:
Wang et al. 2001. DR3 regulates negative selection during thymocyte development. Molecular and Cellular Biology. 21:3451-61.
Applications & Therapeutic Areas
- Oncology & Immuno-Oncology
Transit, Housing & Welfare
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- Licensing
- Pricing - USD
- Pricing - EUR
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DR3 Knockout Mouse
Customers may purchase this model by signing the appropriate Terms of Sale (below) and providing a PO.
This model is sold under terms which grant perpetual use rights.
This model is sold under terms which grant perpetual use rights.
Pricing - USD
14096
| Item | Commercial | Nonprofit |
|---|---|---|
| Cryopreserved Model | $21,000.00 | $13,000.00 |
Cryopreserved models are invoiced upon shipment of recovered animals. Once orders are placed, the full purchase price will be applied if the order is canceled. For orders greater than 4 animals, please contact Taconic for options.
Fees for Taconic Transit Cages™ and freight are in addition to the price above.
Pricing - EUR
14096
| Item | Commercial | Nonprofit |
|---|---|---|
| Cryopreserved Model | €21.000,00 | €13.000,00 |
Cryopreserved models are invoiced upon shipment of recovered animals. Once orders are placed, the full purchase price will be applied if the order is canceled. For orders greater than 4 animals, please contact Taconic for options.
Fees for Taconic Transit Cages™ and freight are in addition to the price above.
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