| Model No. | Nomenclature | Genotype |
|---|---|---|
| 14090 | B6;129-Jag1tm1Jlew | Inquire for genotype |
Floxed Jagged1 Mouse
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Overview
Nomenclature: B6;129-Jag1tm1Jlew
- May be used to generate constitutive or conditional knockouts of the Jagged 1 gene by crossing to the cre line of choice.
- The conditional Jag1 knockout is useful for in vivo studies focused on tissue specific Jag1 knockouts.
- This line can also be used to study Notch signaling.
Origin
The Jagged 1 conditional knockout was developed in the laboratory of Julian Lewis at the London Research Institute. A Jagged 1 targeting vector, containing a loxP flanked resistance cassette before exon 4 and a loxP site inserted after exon 5, was transfected into 129 ES cells. Properly targeted ES cells were transfected with a Cre expression vector to excise the resistance cassette, and injected into a C57BL6 blastocyst. Chimeric offspring were mated on a C57BL6 background. Taconic received embryos from CRT in 2015.
Source: Cancer Research Technology (CRT)
This model is cryopreserved and available for recovery. Models can typically be recovered and delivered to customers within 12 weeks after order receipt. Purchase of this model includes perpetual use rights and a deliverable of four mutant animals at the Murine Pathogen Free™ health standard along with a genotyping protocol. For models which include a recombinase gene or multiple alleles, all alleles will be provided, but individual animals may not contain all mutant alleles.
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Genetics
Guides & Publications
Initial Publication:
Brooker et al. 2006. Notch ligands with contrasting functions: Jagged1 and Delta1 in the mouse inner ear. Development. 133:1277-86.
Applications & Therapeutic Areas
- Oncology & Immuno-Oncology
Transit, Housing & Welfare
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- Licensing
- Pricing - USD
- Pricing - EUR
- Select my Health Standard
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Floxed Jagged1 Mouse
Customers may purchase this model by signing the appropriate Terms of Sale (below) and providing a PO.
This model is sold under terms which grant perpetual use rights.
This model is sold under terms which grant perpetual use rights.
Pricing - USD
14090
| Item | Commercial | Nonprofit |
|---|---|---|
| Cryopreserved Model | $21,000.00 | $13,000.00 |
Cryopreserved models are invoiced upon shipment of recovered animals. Once orders are placed, the full purchase price will be applied if the order is canceled. For orders greater than 4 animals, please contact Taconic for options.
Fees for Taconic Transit Cages™ and freight are in addition to the price above.
Pricing - EUR
14090
| Item | Commercial | Nonprofit |
|---|---|---|
| Cryopreserved Model | €21.000,00 | €13.000,00 |
Cryopreserved models are invoiced upon shipment of recovered animals. Once orders are placed, the full purchase price will be applied if the order is canceled. For orders greater than 4 animals, please contact Taconic for options.
Fees for Taconic Transit Cages™ and freight are in addition to the price above.
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