| Model No. | Nomenclature | Genotype |
|---|---|---|
| 14086 | B6.Cg-Gstp1/Gstp2tm1Wolf | Inquire for genotype |
GSTP1/2 Double Knockout Mouse
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Overview
Nomenclature: B6.Cg-Gstp1/Gstp2tm1Wolf
- Double knockout of the glutathione S-transferase, pi 1 and glutathione S-transferase, pi 2 genes
- The Gstp1/2 double knockout is useful for the in vivo study of a Gstp1/2 (regulator of protein synthesis/degradation) function in tumorigenesis, drug metabolism and toxicity.
Origin
The Gstp1/2 double knockout was developed in the laboratory of C. Roland Wolf at the Imperial Cancer Research Fund Molecular Pharmacology Unit, Dundee, United Kingdom. A Gstp1/2 targeting vector, replacing all of the Gstp1 gene and exons 6 and 7 of the Gstp2 gene with a resistance cassette, was transfected into E14Tg2a.IV ES cells. Properly targeted ES cells containing a homologous recombination event were selected, cloned, and injected into blastocysts. Chimeric mice were mated with MF1 mice to generate mice heterozygous for GSTP1/2 knockout. Heterozygous mice were interbred to generate mice homozygous for GSTP1/2 knockout. Founder lines were backcrossed to C57BL/6. Taconic received embryos from CRT in 2015.
Source: Cancer Research Technology (CRT)
This model is cryopreserved and available for recovery. Models can typically be recovered and delivered to customers within 12 weeks after order receipt. Purchase of this model includes perpetual use rights and a deliverable of four mutant animals at the Murine Pathogen Free™ health standard along with a genotyping protocol. For models which include a recombinase gene or multiple alleles, all alleles will be provided, but individual animals may not contain all mutant alleles.
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Genetics
Guides & Publications
Initial Publication:
Henderson CJ et al. 1998. Increased skin tumorigenesis in mice lacking pi class glutathione S-transferases. Proceedings of the National Academy of Sciences USA. 95:5275-80.
Applications & Therapeutic Areas
- Oncology & Immuno-Oncology
Transit, Housing & Welfare
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- Licensing
- Pricing - USD
- Pricing - EUR
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GSTP1/2 Double Knockout Mouse
Customers may purchase this model by signing the appropriate Terms of Sale (below) and providing a PO.
This model is sold under terms which grant perpetual use rights.
This model is sold under terms which grant perpetual use rights.
Pricing - USD
14086
| Item | Commercial | Nonprofit |
|---|---|---|
| Cryopreserved Model | $21,000.00 | $13,000.00 |
Cryopreserved models are invoiced upon shipment of recovered animals. Once orders are placed, the full purchase price will be applied if the order is canceled. For orders greater than 4 animals, please contact Taconic for options.
Fees for Taconic Transit Cages™ and freight are in addition to the price above.
Pricing - EUR
14086
| Item | Commercial | Nonprofit |
|---|---|---|
| Cryopreserved Model | €21.000,00 | €13.000,00 |
Cryopreserved models are invoiced upon shipment of recovered animals. Once orders are placed, the full purchase price will be applied if the order is canceled. For orders greater than 4 animals, please contact Taconic for options.
Fees for Taconic Transit Cages™ and freight are in addition to the price above.
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