| Model No. | Nomenclature | Genotype |
|---|---|---|
| 9512 | C57BL/6-Gt(ROSA)26Sortm1 (CAG-Mir34a)Mrl | Inquire for genotype |
Mir34a - Model 9512 - cTTG
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Overview
Nomenclature: C57BL/6-Gt(ROSA)26Sortm1 (CAG-Mir34a)Mrl
- The targeting vector has been transfected into TaconicArtemis C57Bl/6 ES cell line.
- The following elements have been inserted into the ROSA26 locus: a CAG promoter cassette; a loxP-flanked transcription termination cassette (STOP) containing a combination of polyadenylation signals; the miR30-miR34a transgene and a polyadenylation site (hGH polyA).
- The conditional TTG line has been generated by crossing chimeras to C57BL/6NTac animals.
- The constitutive TTG allele can be generated by Cre-mediated recombination by crossing line 9512 to a Cre-Deleter.
- Deletion of the STOP cassette should result in transcription of the miR30-miR34a transgene.
- The presence of the NeoR cassette will terminate the transcription from the ROSA26 promoter.
- Datamining and Design performed in 2008.
Source: TaconicArtemis
This model is cryopreserved and available for recovery. Models can typically be recovered and delivered to customers within 12 weeks after order receipt. Purchase of this model includes perpetual use rights and a deliverable of four mutant animals at the Murine Pathogen Free™ health standard along with a genotyping protocol. For models which include a recombinase gene or multiple alleles, all alleles will be provided, but individual animals may not contain all mutant alleles.
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Mir34a - Model 9512 - cTTG
Customers may purchase this model by signing the appropriate Terms of Sale (below) and providing a PO.
The GEM Collection Commercial and Academic/Non-Profit Terms of Sale grant perpetual use rights.
| Item | Commercial | Nonprofit |
| Cryopreserved Model | $32,500 | $5,500 |
| Item | Commercial | Nonprofit |
| Cryopreserved Model | €29.500 | €5.005 |
Cryopreserved models are invoiced upon shipment of recovered animals. Once orders are placed, the full purchase price will be applied if the order is canceled. For orders greater than 4 animals, please contact Taconic for options.
Fees for Taconic Transit Cages™ and freight are in addition to the price above.
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