| Model No. | Nomenclature | Genotype |
|---|---|---|
| 10898 | C57BL/6-Pcsk9 tm1.1 Mrl | Inquire for genotype |
Pcsk9 - Model 10898 - cKO
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Overview
Nomenclature: C57BL/6-Pcsk9 tm1.1 Mrl
- The targeting vector has been generated using C57BL/6J DNA and transfected into Taconic’s C57BL/6N Tac ES cell line.
- Pcsk9 exon 1 contains the translation initiation codon.
- Exons 2 and 3 have been flanked by loxP sites including the FRT site flanked neomycin resistance gene cassette.
- The neomycin resistance gene cassette has been removed by transient transfection of Flp recombinase into targeted ES cell clones.
- The conditional KO line has been derived using C57BL/6NTac animals.
- The constitutive KO allele can be generated by Cre-mediated recombination.
- Deletion of exons 2 and 3 should result in loss of function of the Pcsk9gene.
- The remaining recombination sites are located in non-conserved regions of the genome.
- Datamining and Design performed in 2010.
Official Gene Symbol: Pcsk9
Availability
Cryopreserved at TaconicSource: Xenogen
This model is cryopreserved and available for recovery. Models can typically be recovered and delivered to customers within 12 weeks after order receipt. Purchase of this model includes perpetual use rights and a deliverable of four mutant animals at the Murine Pathogen Free™ health standard along with a genotyping protocol. For models which include a recombinase gene or multiple alleles, all alleles will be provided, but individual animals may not contain all mutant alleles.
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Genetics
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Transit, Housing & Welfare
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Pcsk9 - Model 10898 - cKO
Customers may purchase this model by signing the appropriate Terms of Sale (below) and providing a PO.
The GEM Collection Commercial and Academic/Non-Profit Terms of Sale grant perpetual use rights.
| Item | Commercial | Nonprofit |
| Cryopreserved Model | $32,500 | $5,500 |
| Item | Commercial | Nonprofit |
| Cryopreserved Model | €29.500 | €5.005 |
Cryopreserved models are invoiced upon shipment of recovered animals. Once orders are placed, the full purchase price will be applied if the order is canceled. For orders greater than 4 animals, please contact Taconic for options.
Fees for Taconic Transit Cages™ and freight are in addition to the price above.
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