| Model No. | Nomenclature | Genotype |
|---|---|---|
| SJL-F | SJL/JCrNTac | |
| SJL-M | SJL/JCrNTac |
SJL
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Overview
Nomenclature: SJL/JCrNTac
- Exhibits a high incidence of reticulum cell sarcomas at approximately 12 months of age; resembles Hodgkin's Disease
- Due to the SJL's resistance to diet-induced athlerosclerosis the model is also useful for Cardiovascular Research
- Carries the H2s haplotype and the mutation for retinal degeneration, Pde6brd1
- The SJL is used as the male parent to produce the B6SJLF1 hybrid which is often used as the pronuclear cell donor in transgenic microinjection laboratories
Origin
The SJL inbred model was developed by Lambert et al of the Jackson Laboratory in 1955 from Swiss Webster outbred mice of three origins. The Cancer Research Center received stock from the Jackson Laboratory. The NIH Genetic Resource received stock from the Cancer Research Center. Taconic received stock at F9+ from the NIH Genetic Resource in 1999. The mice were derived by embryo transfer in 2000. The Taconic foundation colony was at F29 in 2005.
Genetics
Guides & Publications
Applications & Therapeutic Areas
- Cardiovascular Disease
- Immunology
- Inflammation
- Oncology & Immuno-Oncology
Transit, Housing & Welfare
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Males are exceptionally aggressive. SJL males are packed as cagemates, without recombination of animals from different cages into a single Taconic Transit Cage (TTC). We recommend that customers do NOT recombine SJL males from different Taconic Transit Cages into the same cage at or after unpacking.
Packing Practices
Taconic standard practice is to recombine animals of different home cages and/or ages from a single model and sex during packing, except in specific cases where Taconic's animal welfare policy prohibits recombination due to aggression or other concerns. When an order is fulfilled with animals from more than one week of birth, this standard practice results in animals from a range of birth weeks packed together in a single TTC. When an order is fulfilled with animals from genotyped models, this standard practice results in animals from different home cages packed together in a single TTC.
Customers who wish to keep animals from different weeks of birth separated should place orders with the special instruction "Divide and label by age." Note that this special request can result in increased costs for additional Taconic Transit Cages, dividers and/or freight charges.
Taconic discourages other types of custom packing requests as they can have a negative impact on animal welfare. Learn more.
Diet
Data
Average litter size: 5
Orders by weight: Taconic cannot routinely accept orders by weight for this model due to colony size. Please inquire for options if weight is critical for your experiment.
n= 100 per sex at MPF, health standard from all global colonies. Data collected 2011-15.
High and Low represent mean +/- 2 standard deviations.
Based on sample size the charts above represents ~90% of the population.
All growth curves represent animals housed in our barriers, at our standard density and fed NIH31-M diet. Variations at customer facilities will alter expected growth curves.
Growth charts are provided only as a guide, if a specific weight criteria is needed please order animals by weight.
- Pricing - USD
- Pricing - EUR
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Pricing - USD
Murine Pathogen Free (MPF) Health Standard
SJL Female
SJL-F
| Age in Weeks | Quantity 1 - 999 |
| 3 to 4 | $120.00 |
| 5 to 6 | $148.00 |
| 7 to 9 | $174.00 |
Specialized Inventory
| SJL-FL | Quantity 1 - 199 |
| Female With Litter | $967.00 |
Specialized Inventory
| SJL-UP | Quantity 1 - 199 |
| Untimed Pregnant Female | $645.00 |
*Untimed pregnant requests are filled with late gestation pregnant females. Pups may be delivered in transit.
SJL Male
SJL-M
| Age in Weeks | Quantity 1 - 999 |
| 3 to 4 | $108.00 |
| 5 to 6 | $120.00 |
| 7 to 9 | $148.00 |
Pricing - EUR
Murine Pathogen Free (MPF) Health Standard
SJL Female
SJL-F
| Age in Weeks | Quantity 1 - 999 |
| 3 to 4 | €138,00 |
| 5 to 7 | €180,00 |
| 8 to 9 | €211,00 |
SJL Male
SJL-M
| Age in Weeks | Quantity 1 - 999 |
| 3 to 4 | €122,00 |
| 5 to 7 | €151,00 |
| 8 to 9 | €174,00 |
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