TSG-p53® - Model P53N12

TSG-p53® (Model P53N12) Constitutive Knockout Mouse Model
  • Cryopreserved
  • Mouse
  • Male Only
  • Not available for direct purchase by CRO
Model No.NomenclatureGenotype
P53N12B6.129-Trp53tm1Brd N12Inquire for genotype
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Overview

Nomenclature: B6.129-Trp53tm1Brd N12

  • Contains a disruption of the p53 tumor suppressor gene, the most commonly mutated gene in human cancers
  • Useful for studying p53 gene function or screening potential cancer intervention therapies
  • Homozygous TSG-p53® mice are totally deficient in p53 protein and prone to the development of spontaneous tumors, primarily lymphomas and sarcomas
  • Heterozygous TSG-p53® mice carry one normal p53 allele and have a low rate of spontaneous tumor development
  • Differs from Model P53N5-T in that P53N12-T has been backcrossed for an additional seven generations, thereby reducing genes from the 129 strain

Availability

Available for immediate cryorecovery

Origin

The TSG-p53® mouse was developed in the laboratory of Lawrence A. Donehower and Allan Bradley at the Baylor College of Medicine. The model was created by targeting the Trp53 gene in AB1 ES cells and injecting the targeted cells into C57BL/6 blastocysts. Resultant chimeras were backcrossed to C57BL/6J for two generations (N2). Taconic received stock in 1991. The mice were backcrossed to N3 for caesarean derivation and to N4 immediately after derivation. In 1995, backcrossing of the N4 heterozygote to C57BL/6NTac mice recommenced at Taconic and continued to twelve generations (N12). The line was embryo transfer derived in 1998. Heterozygous and homozygous mice are maintained at N12 through mating of homozygous male mice with heterozygous females.

This model is cryopreserved and available for recovery. Models can typically be recovered and delivered to customers within 12 weeks after order receipt. Purchase of this model includes perpetual use rights and a deliverable of four mutant animals at the Murine Pathogen Free™ health standard along with a genotyping protocol. For models which include a recombinase gene or multiple alleles, all alleles will be provided, but individual animals may not contain all mutant alleles.

Taconic’s Colony Management experts can design a plan to grow your colony faster.

Genetics

Species:Mouse
Strain Type:Congenic
Allele Type:Constitutive Knockout
Genetic Background:C57BL/6

Other Genetic Notes:

Wild type for Nnt mutation

Guides & Publications

Initial Publication: Donehower LA, Harvey M, Slagle BL, McArthur MJ, Montgomery CA, Jr, Butel JS, Bradley A. (1992) Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumors. Nature, 356:215-221.

Applications & Therapeutic Areas

  • Oncology & Immuno-Oncology

Transit, Housing & Welfare

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TSG-p53® - Model P53N12

Customers may purchase this model by signing the appropriate Terms of Sale (below) and providing a PO.
This model is sold under terms which grant perpetual use rights.

Pricing - USD

P53N12

ItemCommercialNonprofit
Cryopreserved Model$21,000.00$13,000.00

Cryopreserved models are invoiced upon shipment of recovered animals. Once orders are placed, the full purchase price will be applied if the order is canceled. For orders greater than 4 animals, please contact Taconic for options.

Fees for Taconic Transit Cages™ and freight are in addition to the price above.

Pricing - EUR

P53N12

ItemCommercialNonprofit
Cryopreserved Model€21.000,00€13.000,00

Cryopreserved models are invoiced upon shipment of recovered animals. Once orders are placed, the full purchase price will be applied if the order is canceled. For orders greater than 4 animals, please contact Taconic for options.

Fees for Taconic Transit Cages™ and freight are in addition to the price above.

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Get your Taconic Biosciences 2024 Pricing Guide today. Personalized, customizable, links to up-to-date health reports, and additional information on Taconic's products and services.