| Model No. | Nomenclature | Genotype |
|---|---|---|
| B2MN12 | Inquire for genotype | Inquire for genotype |
B2m (β2m)
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- Related Products & Services
- Price & Licensing
- Overview
- Genetics
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- Transit, Housing & Welfare
- Diet
Overview
- Contains a disruption of the beta-2-microglobulin gene
- Deficient in MHC Class I molecule expression
- Exhibits depletion of CD8+ T cells
- Lack the NK1.1+ CD4+ T-cell population as well, because of dependence on MHC Class 1b molecule CD1 for development
- Useful in transplantation, gene therapy, and immunological disease research
Origin
This model is cryopreserved and available for recovery. Models can typically be recovered and delivered to customers within 14-16 weeks after order receipt. Purchase of this model includes perpetual use rights and a deliverable of four mutant animals at the Murine Pathogen Free™ health standard along with a genotyping protocol. For models which include a recombinase gene or multiple alleles, all alleles will be provided, but individual animals may not contain all mutant alleles.
Taconic’s Colony Management experts can design a plan to grow your colony faster.
Genetics
Guides & Publications
Initial Publication: Zijlstra M, Bix M, Simister NE, Loring JM, Raulet DH, Jaenisch R. (1990) β2-Microglobulin deficient mice lack CD4-8+ cytolytic T cells, Nature, 344(6268):742-746.
Applications & Therapeutic Areas
- Immunology
- Inflammation
Transit, Housing & Welfare
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Diet
- Services
- Licensing
- Pricing - USD
- Pricing - EUR
- Select my Health Standard
- Get Custom Pricing Guide
B2m (β2m)
Customers may purchase this model by signing the appropriate Terms of Sale (below) and providing a PO.
This model is sold under terms which grant perpetual use rights.
This model is sold under terms which grant perpetual use rights.
Pricing - USD
B2MN12
| Item | Commercial | Nonprofit |
|---|---|---|
| Cryopreserved Model | $23,100.00 | $17,325.00 |
Cryopreserved models are invoiced upon shipment of recovered animals. Once orders are placed, the full purchase price will be applied if the order is canceled. For orders greater than 4 animals, please contact Taconic for options.
Fees for Taconic Transit Cages™ and freight are in addition to the price above.
Pricing - EUR
B2MN12
| Item | Commercial | Nonprofit |
|---|---|---|
| Cryopreserved Model | €21.000,00 | €15.855,00 |
Cryopreserved models are invoiced upon shipment of recovered animals. Once orders are placed, the full purchase price will be applied if the order is canceled. For orders greater than 4 animals, please contact Taconic for options.
Fees for Taconic Transit Cages™ and freight are in addition to the price above.
Select my Health Standard
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Use the Health Standard Selector to enter your exclusion list. The tool will tell you which health standards meet your requirements.
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