| Model No. | Nomenclature | Genotype |
|---|---|---|
| B2MN12 | Inquire for genotype | Inquire for genotype |
B2m (β2m)
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- Description
- Related Products & Services
- Price & Licensing
- Overview
- Genetics
- Guides & Publications
- Applications & Therapeutic Areas
- Transit, Housing & Welfare
- Diet
Overview
- Contains a disruption of the beta-2-microglobulin gene
- Deficient in MHC Class I molecule expression
- Exhibits depletion of CD8+ T cells
- Lack the NK1.1+ CD4+ T-cell population as well, because of dependence on MHC Class 1b molecule CD1 for development
- Useful in transplantation, gene therapy, and immunological disease research
Origin
This model is cryopreserved and available for recovery. Models can typically be recovered and delivered to customers within 12 weeks after order receipt. Purchase of this model includes perpetual use rights and a deliverable of four mutant animals at the Murine Pathogen Free™ health standard along with a genotyping protocol. For models which include a recombinase gene or multiple alleles, all alleles will be provided, but individual animals may not contain all mutant alleles.
Taconic’s Colony Management experts can design a plan to grow your colony faster.
Genetics
Guides & Publications
Initial Publication: Zijlstra M, Bix M, Simister NE, Loring JM, Raulet DH, Jaenisch R. (1990) β2-Microglobulin deficient mice lack CD4-8+ cytolytic T cells, Nature, 344(6268):742-746.
Applications & Therapeutic Areas
- Immunology
- Inflammation
Transit, Housing & Welfare
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Diet
- Services
- Licensing
- Pricing - USD
- Pricing - EUR
- Select my Health Standard
- Get Custom Pricing Guide
B2m (β2m)
Customers may purchase this model by signing the appropriate Terms of Sale (below) and providing a PO.
This model is sold under terms which grant perpetual use rights.
This model is sold under terms which grant perpetual use rights.
Pricing - USD
B2MN12
| Item | Commercial | Nonprofit |
|---|---|---|
| Cryopreserved Model | $23,100.00 | $17,325.00 |
Cryopreserved models are invoiced upon shipment of recovered animals. Once orders are placed, the full purchase price will be applied if the order is canceled. For orders greater than 4 animals, please contact Taconic for options.
Fees for Taconic Transit Cages™ and freight are in addition to the price above.
Pricing - EUR
B2MN12
| Item | Commercial | Nonprofit |
|---|---|---|
| Cryopreserved Model | €21.000,00 | €15.855,00 |
Cryopreserved models are invoiced upon shipment of recovered animals. Once orders are placed, the full purchase price will be applied if the order is canceled. For orders greater than 4 animals, please contact Taconic for options.
Fees for Taconic Transit Cages™ and freight are in addition to the price above.
Select my Health Standard
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Use the Health Standard Selector to enter your exclusion list. The tool will tell you which health standards meet your requirements.
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