| Model No. | Nomenclature | Genotype |
|---|---|---|
| 8263 | C57BL/6-Bace1tm1.1mrl | Inquire for genotype |
Bace1 - Model 8263 - cKO
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Overview
Nomenclature: C57BL/6-Bace1tm1.1mrl
- The targeting vector has been generated using C57BL/6J DNA and transfected into C57BL/6NTac ES cell line.
- Bace1 exon 1 contains the translation initiation codon.
- Exon 2 has been flanked by loxP sites.
- The conditional KO allele has been generated after Flp-mediated recombination by crossing chimeras to a Flp-Deleter on a C57BL/6 background.
- The conditional KO line has been subsequently backcrossed to C57BL/6NTac animals for at least 2 generations and the Flp-transgene was removed by segregation.
- The constitutive KO allele can be generated by Cre-mediated recombination. Deletion of exon 2 should result in loss of function of the Bace1 gene by generating a frameshift (premature Stop codon in exon 3).
- The remaining recombination sites are located in intron regions of the genome.
- Datamining and Design performed in 2007.
Availability
Cryopreserved at TaconicSource: Institut Clinique de la Souris (ICS), Illkirch, France
This model is cryopreserved and available for recovery. Models can typically be recovered and delivered to customers within 12 weeks after order receipt. Purchase of this model includes perpetual use rights and a deliverable of four mutant animals at the Murine Pathogen Free™ health standard along with a genotyping protocol. For models which include a recombinase gene or multiple alleles, all alleles will be provided, but individual animals may not contain all mutant alleles.
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Genetics
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Transit, Housing & Welfare
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Bace1 - Model 8263 - cKO
Customers may purchase this model by signing the appropriate Terms of Sale (below) and providing a PO.
The GEM Collection Commercial and Academic/Non-Profit Terms of Sale grant perpetual use rights.
| Item | Commercial | Nonprofit |
| Cryopreserved Model | $32,500 | $5,500 |
| Item | Commercial | Nonprofit |
| Cryopreserved Model | €29.500 | €5.005 |
Cryopreserved models are invoiced upon shipment of recovered animals. Once orders are placed, the full purchase price will be applied if the order is canceled. For orders greater than 4 animals, please contact Taconic for options.
Fees for Taconic Transit Cages™ and freight are in addition to the price above.
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