Bmx-CreERT2 Mouse

Bmx-CreERT2 Random Transgenic Mouse Model
  • Cryopreserved
  • Mouse
  • Not available for direct purchase by CRO
Model No.NomenclatureGenotype
14081C57BL/6J-Tg(Bmx-cre/ERT2)1RhaInquire for genotype
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Overview

Nomenclature: C57BL/6J-Tg(Bmx-cre/ERT2)1Rha

  • An inducible cre deleter under the control of the BMX non-receptor tyrosine kinase promoter.
  • Cre recombination is inducible via administration of tamoxifen.
  • Useful for study of angiogenesis, atherosclerosis and neovascularization.
  • Non-induced Bmx-CreERT2 mice demonstrate no Cre recombinase activity, while tamoxifen-induced Bmx-CreERT2 mice demonstrate high levels of recombinase-mediated gene deletion in endothelial cells (95%+).

Origin

The Bmx-Cre-ERT2 mouse was developed in the laboratory of Ralf Adams at the London Research Institute. The model was generated by microinjecting a transgene containing a genomic Bmx promoter fragment fused to a CreERT2 cDNA into B6xCBA F1 zygotes. Founder lines were backcrossed to C57BL/6 for at least five generations. Taconic received embryos from CRT in 2015.

Source: Cancer Research Technology (CRT)

This model is cryopreserved and available for recovery. Models can typically be recovered and delivered to customers within 14-16 weeks after order receipt. Purchase of this model includes perpetual use rights and a deliverable of four mutant animals at the Murine Pathogen Free™ health standard along with a genotyping protocol. For models which include a recombinase gene or multiple alleles, all alleles will be provided, but individual animals may not contain all mutant alleles.

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Genetics

Species:Mouse
Strain Type:Congenic
Allele Type:Recombinase-expressing;Random Transgenic
Genetic Background:C57BL/6

Guides & Publications

Applications & Therapeutic Areas

  • Oncology & Immuno-Oncology
  • Recombinase-mediated Gene Deletion

Transit, Housing & Welfare

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Bmx-CreERT2 Mouse

Customers may purchase this model by signing the appropriate Terms of Sale (below) and providing a PO.
This model is sold under terms which grant perpetual use rights.

Pricing - USD

14081

ItemCommercialNonprofit
Cryopreserved Model$36,750.00$14,700.00

Cryopreserved models are invoiced upon shipment of recovered animals. Once orders are placed, the full purchase price will be applied if the order is canceled. For orders greater than 4 animals, please contact Taconic for options.

Fees for Taconic Transit Cages™ and freight are in addition to the price above.

Pricing - EUR

14081

ItemCommercialNonprofit
Cryopreserved Model€33.390,00€13.125,00

Cryopreserved models are invoiced upon shipment of recovered animals. Once orders are placed, the full purchase price will be applied if the order is canceled. For orders greater than 4 animals, please contact Taconic for options.

Fees for Taconic Transit Cages™ and freight are in addition to the price above.

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Get your Taconic Biosciences 2024 Pricing Guide today. Personalized, customizable, links to up-to-date health reports, and additional information on Taconic's products and services.