Humanized CAR Mouse

Humanized CAR Targeted Replacement Mouse Model
  • Cryopreserved
  • Mouse
  • Male Only
  • Black
  • Not available for direct purchase by CRO
Model No.NomenclatureGenotype
9101C57BL/6-Nr1i3tm1(NR1I3)ArteInquire for genotype
View:
Select One

Overview

Nomenclature: C57BL/6-Nr1i3tm1(NR1I3)Arte

  • This targeted mutation strain carries a replacement of the mouse Nr1i3 gene which encodes for the nuclear receptor CAR with the corresponding human orthologous gene.
  • Useful in prediction of CYP induction and therefore pharmacokinetics, drug toxicity, and efficacy in humans.

Origin

The Humanized CAR Mouse was developed by Taconic in collaboration with CXR Biosciences. It was created through a knock in of a human CAR construct containing the genomic sequence from the translational start site on exon 2 to exon 9 onto the ATG of murine Car in C57BL/6NTac-derived ES cells. The expression of the human CAR receptor is driven by the mouse Car promoter. Targeted ES cells were injected into BALB/cJBomTac blastocysts and the resultant chimeras were backcrossed to a Flpe deleter strain on C57BL/6J to eliminate the selection marker. Taconic received stock in 2009, and the line was embryo transfer derived. The colony was maintained by mating homozygotes.

This model is cryopreserved and available for recovery. Models can typically be recovered and delivered to customers within 14-16 weeks after order receipt. Purchase of this model includes perpetual use rights and a deliverable of four mutant animals at the Murine Pathogen Free™ health standard along with a genotyping protocol. For models which include a recombinase gene or multiple alleles, all alleles will be provided, but individual animals may not contain all mutant alleles.

Taconic’s Colony Management experts can design a plan to grow your colony faster.

Genetics

Species:Mouse
Strain Type:Inbred
Allele Type:Knock-in;Genetically Humanized
Coat Color:Black
Genetic Background:C57BL/6

Guides & Publications

Initial Publication: Scheer N, Ross J, Rode A, Zevnik B, Niehaves S, Faust N, Wolf CR. (2008) A novel panel of mouse models to evaluate the role of human pregnane X receptor and constitutive androstane receptor in drug response. J. Clin. Invest. 118(9): 3228-3239.

Applications & Therapeutic Areas

  • ADMET

Transit, Housing & Welfare

Need more info? Click the live chat button or Contact Us

tADMET™ Portfolio

mouse

Contract Services

mouse

Humanized CAR Mouse

Customers may purchase this model by signing the appropriate Terms of Sale (below) and providing a PO.
This model is sold under terms which grant perpetual use rights.

Pricing - USD

9101

ItemCommercialNonprofit
Cryopreserved Model$29,400.00$21,000.00

Cryopreserved models are invoiced upon shipment of recovered animals. Once orders are placed, the full purchase price will be applied if the order is canceled. For orders greater than 4 animals, please contact Taconic for options.

Fees for Taconic Transit Cages™ and freight are in addition to the price above.

Pricing - EUR

9101

ItemCommercialNonprofit
Cryopreserved Model€26.250,00€19.425,00

Cryopreserved models are invoiced upon shipment of recovered animals. Once orders are placed, the full purchase price will be applied if the order is canceled. For orders greater than 4 animals, please contact Taconic for options.

Fees for Taconic Transit Cages™ and freight are in addition to the price above.

Select my Health Standard

Need help choosing the right Taconic Biosciences health standard for your research?

Use the Health Standard Selector to enter your exclusion list. The tool will tell you which health standards meet your requirements.

Get custom pricing guide

2024 Pricing Guide Now Available

Get your Taconic Biosciences 2024 Pricing Guide today. Personalized, customizable, links to up-to-date health reports, and additional information on Taconic's products and services.

Want to Get in Touch?

Chat with us or reach out to our global team

phone

2024 Pricing Guide Now Available

Get your Taconic Biosciences 2024 Pricing Guide today. Personalized, customizable, links to up-to-date health reports, and additional information on Taconic's products and services.