| Model No. | Nomenclature | Genotype |
|---|---|---|
| 10393 | C57BL/6-Car1tm1.2mrl | Inquire for genotype |
Car1 - Model 10393 - KO
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Overview
Nomenclature: C57BL/6-Car1tm1.2mrl
- The targeting vector has been generated using C57BL/6J DNA and transfected into TaconicArtemis C57BL/6NTac ES cell line.
- Exon 2 contains the translation initiation codon.
- Exon 4 has been flanked by loxP sites (size of loxP-flanked region: 1.5 kb).
- The constitutive KO allele has been generated after Cre-mediated recombination by crossing chimeras to a Cre-Deleter on a C57BL/6 background.
- The constitutive KO line has been derived using C57BL/6NTac animals and the Cre-transgene was removed by segregation.
- Deletion of exon 4 should result in loss of function of the Car1 gene by deleting part of the catalytic domain (including residues H95 and H97 described as Zn+-binding sites (SwissProt #P13634)) and by generating a frameshift from exon 3 to exons 5-8 (premature Stop codon in exon 5).
- Datamining and Design performed in 2009.
Availability
Cryopreserved at TaconicSource: TaconicArtemis
This model is cryopreserved and available for recovery. Models can typically be recovered and delivered to customers within 12 weeks after order receipt. Purchase of this model includes perpetual use rights and a deliverable of four mutant animals at the Murine Pathogen Free™ health standard along with a genotyping protocol. For models which include a recombinase gene or multiple alleles, all alleles will be provided, but individual animals may not contain all mutant alleles.
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Genetics
Guides & Publications
Transit, Housing & Welfare
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Car1 - Model 10393 - KO
Customers may purchase this model by signing the appropriate Terms of Sale (below) and providing a PO.
The GEM Collection Commercial and Academic/Non-Profit Terms of Sale grant perpetual use rights.
| Item | Commercial | Nonprofit |
| Cryopreserved Model | $32,500 | $5,500 |
| Item | Commercial | Nonprofit |
| Cryopreserved Model | €29.500 | €5.005 |
Cryopreserved models are invoiced upon shipment of recovered animals. Once orders are placed, the full purchase price will be applied if the order is canceled. For orders greater than 4 animals, please contact Taconic for options.
Fees for Taconic Transit Cages™ and freight are in addition to the price above.
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