| Model No. | Nomenclature | Genotype |
|---|---|---|
| 11521 | FVB/NTac-Tg(CRE/Tk-luc)219Hgp | Inquire for genotype |
CRE-Luc GPCR Reporter Mouse, Line 219
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Overview
Nomenclature: FVB/NTac-Tg(CRE/Tk-luc)219Hgp
- Expresses luciferase under the control of the cAMP response element (CRE)
- GPCR signaling through the cAMP pathway can be detected from the target. GPCR that is in a native cellular environment with a full complement of associated receptors and membrane constituents
- Luciferase is expressed primarily in the high basal, kidney, brain, pancreas, and lungs in Line 219
- Useful for screening in vivo, in vitro, and ex vivo using whole animals, tissues, and primary cells
- Learn more about the CRE-Luc GPCR Reporter Mouse Platform
Orders by weight: Taconic cannot accept orders by weight for this model. Please note that shipments may contain animals with a larger weight variation.
This model is cryopreserved and available for recovery. Models can typically be recovered and delivered to customers within 12 weeks after order receipt. Purchase of this model includes perpetual use rights and a deliverable of four mutant animals at the Murine Pathogen Free™ health standard along with a genotyping protocol. For models which include a recombinase gene or multiple alleles, all alleles will be provided, but individual animals may not contain all mutant alleles.
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Genetics
Guides & Publications
Initial Publication:
- Pang Z, Wu N, Zhang X, Avallone R, Croci T, Dressler H, Palejwala V, Ferrara P, Tocci MJ, Polites HG. (2010) GPR40 is partially required for insulin secretion following activation of b3-adrenergic receptors. Mol Cell Endocrinol 325(1-2):18-25
Applications & Therapeutic Areas
- Reporter Lines
Transit, Housing & Welfare
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Diet
- Services
- Licensing
- Pricing - USD
- Pricing - EUR
- Select my Health Standard
- Get Custom Pricing Guide
Licensing
Customers may purchase this model by signing the appropriate Terms of Sale (below) and providing a PO.
This model is sold under terms which grant perpetual use rights.
This model is sold under terms which grant perpetual use rights.
Pricing - USD
11521
| Item | Commercial | Nonprofit |
|---|---|---|
| Cryopreserved Model | $21,000.00 | $13,000.00 |
Cryopreserved models are invoiced upon shipment of recovered animals. Once orders are placed, the full purchase price will be applied if the order is canceled. For orders greater than 4 animals, please contact Taconic for options.
Fees for Taconic Transit Cages™ and freight are in addition to the price above.
Pricing - EUR
11521
| Item | Commercial | Nonprofit |
|---|---|---|
| Cryopreserved Model | €21.000,00 | €13.000,00 |
Cryopreserved models are invoiced upon shipment of recovered animals. Once orders are placed, the full purchase price will be applied if the order is canceled. For orders greater than 4 animals, please contact Taconic for options.
Fees for Taconic Transit Cages™ and freight are in addition to the price above.
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