| Model No. | Nomenclature | Genotype |
|---|---|---|
| 8841 | C57BL/6NTac-Del(5Cyp3a57-Cyp3a59)1Arte | Inquire for genotype |
Cyp3a (7-gene) Knockout Mouse
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Overview
Nomenclature: C57BL/6NTac-Del(5Cyp3a57-Cyp3a59)1Arte
- This model carries a deletion of seven full-length mouse Cyp3a genes.
- Contains a cre-mediated deletion of the following genes in the Cyp3a cluster: Cyp3a11, Cyp3a16, Cyp3a25, Cyp3a41, Cyp3a44, Cyp3a57, Cyp3a59.
- In humans, CYP3A enzymes metabolize most drugs.
- Useful in dissecting the contribution of the Cyp3a family to total bioavailability of a drug.
- This model may be used in combination with another model which expresses human CYP3A4 under control of the human CYP3A4 promoter (8842) in order to determine the contribution of CYP3A4-mediated drug metabolism.
Origin
This model is cryopreserved and available for recovery. Models can typically be recovered and delivered to customers within 12 weeks after order receipt. Purchase of this model includes perpetual use rights and a deliverable of four mutant animals at the Murine Pathogen Free™ health standard along with a genotyping protocol. For models which include a recombinase gene or multiple alleles, all alleles will be provided, but individual animals may not contain all mutant alleles.
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Genetics
Guides & Publications
Initial Publication: Scheer N, Ross J, Kapelyukh Y, Rode A, Wolf CR. (2010). In vivo responses of the human and murine pregnane X receptor to dexamethasone in mice. Drug Metab Disp 38(7) 1046-1053.
Additional publication:
Hasegawa M, Kapelyukh Y, Tahara H, Seibler J, Rode A, Krueger S, Lee DN, Wolf CR, Scheer N (2011). Quantitative prediction of human pregnane X receptor and cytochrome P450 3A4 mediated drug-drug interaction in a novel multiple humanized mouse line. Mol Pharmacol 80(3):518-528.
Applications & Therapeutic Areas
- ADMET
Transit, Housing & Welfare
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Diet
- Services
- Licensing
- Pricing - USD
- Pricing - EUR
- Select my Health Standard
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Cyp3a (7-gene) Knockout Mouse
Customers may purchase this model by signing the appropriate Terms of Sale (below) and providing a PO.
This model is sold under terms which grant perpetual use rights.
This model is sold under terms which grant perpetual use rights.
Pricing - USD
8841
| Item | Commercial | Nonprofit |
|---|---|---|
| Cryopreserved Model | $29,400.00 | $21,000.00 |
Cryopreserved models are invoiced upon shipment of recovered animals. Once orders are placed, the full purchase price will be applied if the order is canceled. For orders greater than 4 animals, please contact Taconic for options.
Fees for Taconic Transit Cages™ and freight are in addition to the price above.
Pricing - EUR
8841
| Item | Commercial | Nonprofit |
|---|---|---|
| Cryopreserved Model | €26.250,00 | €17.850,00 |
Cryopreserved models are invoiced upon shipment of recovered animals. Once orders are placed, the full purchase price will be applied if the order is canceled. For orders greater than 4 animals, please contact Taconic for options.
Fees for Taconic Transit Cages™ and freight are in addition to the price above.
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