| Model No. | Nomenclature | Genotype |
|---|---|---|
| 8841 | C57BL/6NTac-Del(5Cyp3a57-Cyp3a59)1Arte | Inquire for genotype |
Cyp3a (7-gene) Knockout Mouse
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Overview
Nomenclature: C57BL/6NTac-Del(5Cyp3a57-Cyp3a59)1Arte
- This model carries a deletion of seven full-length mouse Cyp3a genes.
- Contains a cre-mediated deletion of the following genes in the Cyp3a cluster: Cyp3a11, Cyp3a16, Cyp3a25, Cyp3a41, Cyp3a44, Cyp3a57, Cyp3a59.
- In humans, CYP3A enzymes metabolize most drugs.
- Useful in dissecting the contribution of the Cyp3a family to total bioavailability of a drug.
- This model may be used in combination with another model which expresses human CYP3A4 under control of the human CYP3A4 promoter (8842) in order to determine the contribution of CYP3A4-mediated drug metabolism.
Origin
This model is cryopreserved and available for recovery. Models can typically be recovered and delivered to customers within 14-16 weeks after order receipt. Purchase of this model includes perpetual use rights and a deliverable of four mutant animals at the Murine Pathogen Free™ health standard along with a genotyping protocol. For models which include a recombinase gene or multiple alleles, all alleles will be provided, but individual animals may not contain all mutant alleles.
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Genetics
Guides & Publications
Initial Publication: Scheer N, Ross J, Kapelyukh Y, Rode A, Wolf CR. (2010). In vivo responses of the human and murine pregnane X receptor to dexamethasone in mice. Drug Metab Disp 38(7) 1046-1053.
Additional publication:
Hasegawa M, Kapelyukh Y, Tahara H, Seibler J, Rode A, Krueger S, Lee DN, Wolf CR, Scheer N (2011). Quantitative prediction of human pregnane X receptor and cytochrome P450 3A4 mediated drug-drug interaction in a novel multiple humanized mouse line. Mol Pharmacol 80(3):518-528.
Applications & Therapeutic Areas
- ADMET
Transit, Housing & Welfare
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Diet
- Services
- Licensing
- Pricing - USD
- Pricing - EUR
- Select my Health Standard
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Cyp3a (7-gene) Knockout Mouse
Customers may purchase this model by signing the appropriate Terms of Sale (below) and providing a PO.
This model is sold under terms which grant perpetual use rights.
This model is sold under terms which grant perpetual use rights.
Pricing - USD
8841
| Item | Commercial | Nonprofit |
|---|---|---|
| Cryopreserved Model | $29,400.00 | $21,000.00 |
Cryopreserved models are invoiced upon shipment of recovered animals. Once orders are placed, the full purchase price will be applied if the order is canceled. For orders greater than 4 animals, please contact Taconic for options.
Fees for Taconic Transit Cages™ and freight are in addition to the price above.
Pricing - EUR
8841
| Item | Commercial | Nonprofit |
|---|---|---|
| Cryopreserved Model | €26.250,00 | €17.850,00 |
Cryopreserved models are invoiced upon shipment of recovered animals. Once orders are placed, the full purchase price will be applied if the order is canceled. For orders greater than 4 animals, please contact Taconic for options.
Fees for Taconic Transit Cages™ and freight are in addition to the price above.
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