| Model No. | Nomenclature | Genotype |
|---|---|---|
| 14096 | B6;129-Tnfrsf25tm1Mjo | Inquire for genotype |
DR3 Knockout Mouse
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Overview
Nomenclature: B6;129-Tnfrsf25tm1Mjo
- Knockout of the tumor necrosis factor receptor superfamily, member 25 Tnfrsf25 (also known as Dr3) gene
- Dr3 mediates regulation of the cell division cycle.
- Negative selection and anti-CD3-induced apoptosis are significantly impaired in Dr3-null mice.
Origin
The Dr3 knockout mouse was developed in the laboratory of Eddie Wang at the Imperial Cancer Research Fund, Lincoln's Inn Fields, London. A DR3 targeting vector, replacing the entire DR3 coding region with a loxP flanked resistance cassette, was transfected into GK129 ES cells. Correctly targeted ES cells were injected into C57BL/6 blastocysts. Chimeric offspring were mated to C57BL/6 mice to yield mice heterozygous for the mutant allele. Heterozygous mice were interbred to generate homozygous Dr3-/- mice. Taconic received embryos from CRT in 2015.
Source: Cancer Research Technology (CRT)
This model is cryopreserved and available for recovery. Models can typically be recovered and delivered to customers within 14-16 weeks after order receipt. Purchase of this model includes perpetual use rights and a deliverable of four mutant animals at the Murine Pathogen Free™ health standard along with a genotyping protocol. For models which include a recombinase gene or multiple alleles, all alleles will be provided, but individual animals may not contain all mutant alleles.
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Genetics
Guides & Publications
Initial Publication:
Wang et al. 2001. DR3 regulates negative selection during thymocyte development. Molecular and Cellular Biology. 21:3451-61.
Applications & Therapeutic Areas
- Oncology & Immuno-Oncology
Transit, Housing & Welfare
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- Pricing - USD
- Pricing - EUR
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DR3 Knockout Mouse
Customers may purchase this model by signing the appropriate Terms of Sale (below) and providing a PO.
This model is sold under terms which grant perpetual use rights.
This model is sold under terms which grant perpetual use rights.
Pricing - USD
14096
| Item | Commercial | Nonprofit |
|---|---|---|
| Cryopreserved Model | $23,100.00 | $14,700.00 |
Cryopreserved models are invoiced upon shipment of recovered animals. Once orders are placed, the full purchase price will be applied if the order is canceled. For orders greater than 4 animals, please contact Taconic for options.
Fees for Taconic Transit Cages™ and freight are in addition to the price above.
Pricing - EUR
14096
| Item | Commercial | Nonprofit |
|---|---|---|
| Cryopreserved Model | €21.000,00 | €13.125,00 |
Cryopreserved models are invoiced upon shipment of recovered animals. Once orders are placed, the full purchase price will be applied if the order is canceled. For orders greater than 4 animals, please contact Taconic for options.
Fees for Taconic Transit Cages™ and freight are in addition to the price above.
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