| Model No. | Nomenclature | Genotype |
|---|---|---|
| 579 | C.129S4(B6)-Fcgr2btm1TtK/cAnNTac N12 | Inquire for genotype |
Fcgr2b - Model 579
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- Description
- Price & Licensing
- Overview
- Genetics
- Guides & Publications
- Applications & Therapeutic Areas
- Transit, Housing & Welfare
- Diet
Overview
Nomenclature: C.129S4(B6)-Fcgr2btm1TtK/cAnNTac N12
- Deficient in FcgRIIB protein, which is a low affinity immunoglobulin G receptor
- The FcgRIIB protein inhibits the activation of disparate effector functions such as phagocytosis, antibody dependent cytotoxicity and release of inflammatory mediators and it is known to function as an inhibitory receptor on B cells and mast cells
- This inhibitory pathway for activation of several immune effector responses is dysfunctional, resulting in the inability to regulate antibody levels in response to antigenic stimuli dependent on IgG immune complexes
- Useful for studying the feedback inhibition pathways that regulate antibody production and in studies of allergic and autoimmune disorders
- The mice are fertile and develop normally
- These mice carry the H2d haplotype
Availability
Cryopreserved at Taconic BiosciencesOrigin
This model is cryopreserved and available for recovery. Models can typically be recovered and delivered to customers within 12 weeks after order receipt. Purchase of this model includes perpetual use rights and a deliverable of four mutant animals at the Murine Pathogen Free™ health standard along with a genotyping protocol. For models which include a recombinase gene or multiple alleles, all alleles will be provided, but individual animals may not contain all mutant alleles.
Taconic’s Colony Management experts can design a plan to grow your colony faster.
Genetics
Guides & Publications
Initial Publication: Takai, T, Ono, M, Hikida, M, Ohmori, H, Ravetch, J. (1996) Augmented humoral and anaphylactic responses in FcgRII-deficient mice. Nature, 379: 346-349.
Applications & Therapeutic Areas
- Autoimmune Disease
- Immunology
- Inflammation
- Oncology & Immuno-Oncology
- Vaccine Research
Transit, Housing & Welfare
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Diet
- Licensing
- Pricing - USD
- Pricing - EUR
- Select my Health Standard
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Licensing
Customers may purchase this model by signing the appropriate Terms of Sale (below) and providing a PO.
This model is sold under terms which grant perpetual use rights.
This model is sold under terms which grant perpetual use rights.
Pricing - USD
579
| Item | Commercial | Nonprofit |
|---|---|---|
| Cryopreserved Model | $23,100.00 | $17,325.00 |
Cryopreserved models are invoiced upon shipment of recovered animals. Once orders are placed, the full purchase price will be applied if the order is canceled. For orders greater than 4 animals, please contact Taconic for options.
Fees for Taconic Transit Cages™ and freight are in addition to the price above.
Pricing - EUR
579
| Item | Commercial | Nonprofit |
|---|---|---|
| Cryopreserved Model | €21.000,00 | €15.855,00 |
Cryopreserved models are invoiced upon shipment of recovered animals. Once orders are placed, the full purchase price will be applied if the order is canceled. For orders greater than 4 animals, please contact Taconic for options.
Fees for Taconic Transit Cages™ and freight are in addition to the price above.
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