| Model No. | Nomenclature | Genotype |
|---|---|---|
| 10889 | C57BL/6-Hrh3 tm1.2 Mrl | Inquire for genotype |
Hrh3 - Model 10889 - KO
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Overview
Nomenclature: C57BL/6-Hrh3 tm1.2 Mrl
- The targeting vector has been generated using C57BL/6J DNA and transfected into Taconic’s C57BL/6N Tac ES cell line.
- Hrh3 exon 1 contains the translation initiation codon.
- Exons 1 to 3 have been replaced by the FRT site flanked neomycin resistance gene cassette.
- The neomycin resistance gene cassette has been removed by transient transfection of Flp recombinase into targeted ES cell clones.
- The constitutive KO line has been derived using C57BL/6NTac animals.
- Deletion of exons 1 to 3 should result in loss of function of the Hrh3 gene.
- The remaining recombination sites are located in non-conserved regions of the genome.
- Datamining and Design performed in 2008.
Availability
Cryopreserved at TaconicSource: Xenogen
This model is cryopreserved and available for recovery. Models can typically be recovered and delivered to customers within 14-16 weeks after order receipt. Purchase of this model includes perpetual use rights and a deliverable of four mutant animals at the Murine Pathogen Free™ health standard along with a genotyping protocol. For models which include a recombinase gene or multiple alleles, all alleles will be provided, but individual animals may not contain all mutant alleles.
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Genetics
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Transit, Housing & Welfare
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Hrh3 - Model 10889 - KO
Customers may purchase this model by signing the appropriate Terms of Sale (below) and providing a PO.
The GEM Collection Commercial and Academic Terms of Sale grant perpetual use rights.
| Item | Commercial | Nonprofit |
| Cryopreserved Model | $32,500 | $5,500 |
| Item | Commercial | Nonprofit |
| Cryopreserved Model | €29.500 | €5.005 |
Cryopreserved models are invoiced upon shipment of recovered animals. Once orders are placed, the full purchase price will be applied if the order is canceled. For orders greater than 4 animals, please contact Taconic for options.
Fees for Taconic Transit Cages™ and freight are in addition to the price above.
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