Lrrtm3 - Model 7904 - KO

  • Cryopreserved
  • Mouse
  • Not available for direct purchase by CRO
  • GEM Collection
Model No.NomenclatureGenotype
7904C57BL/6-Lrrtm3tm1.2 MrlInquire for genotype
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Overview

Nomenclature: C57BL/6-Lrrtm3tm1.2 Mrl

  • The targeting vector has been generated using C57BL/6J DNA and transfected into C57BL/6NTac ES cell line.
  • Lrrtm3 exon 1 contains the translation initiation codon.
  • Exon 2 has been flanked by loxP sites.
  • The constitutive KO allele has been generated after Cre-mediated recombination by crossing chimeras to a Cre-Deleter on a C57BL/6 background.
  • The constitutive KO line has been subsequently backcrossed to C57BL/6NTac animals for at least 2 generations and the Cre-transgene was removed by segregation.
  • Deletion of exon 2 should result in loss of function of the Lrrtm3 gene by deleting the Leucine-rich repeat domain.
  • The remaining recombination sites are located in intron regions of the genome.
  • Data mining and design performed in 2006.

Source: Mouse Clinical Institute (MCI)

This model is cryopreserved and available for recovery. Models can typically be recovered and delivered to customers within 14-16 weeks after order receipt. Purchase of this model includes perpetual use rights and a deliverable of four mutant animals at the Murine Pathogen Free™ health standard along with a genotyping protocol. For models which include a recombinase gene or multiple alleles, all alleles will be provided, but individual animals may not contain all mutant alleles.

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Genetics

Species:Mouse
Strain Type:Inbred
Allele Type:Constitutive Knockout
Genetic Background:C57BL/6
Gene Family: Leucine rich repeat
Gene Accession Number: NM_178678
Gene Name: leucine rich repeat transmembrane neuronal 3

7904 WT

0088 cKO

7904 KO

key-allele.jpg

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Lrrtm3 - Model 7904 - KO

Customers may purchase this model by signing the appropriate Terms of Sale (below) and providing a PO.

The GEM Collection Commercial and Academic/Non-Profit Terms of Sale grant perpetual use rights.

    ItemCommercialNonprofit
    Cryopreserved Model$32,500$5,500
      ItemCommercialNonprofit
      Cryopreserved Model€29.500€5.005

       

      Cryopreserved models are invoiced upon shipment of recovered animals. Once orders are placed, the full purchase price will be applied if the order is canceled. For orders greater than 4 animals, please contact Taconic for options.

      Fees for Taconic Transit Cages™ and freight are in addition to the price above.

       

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