Nos2 Knockout

Nos2 Constitutive Knockout Mouse Model
  • Cryopreserved
  • Mouse
  • Not available for direct purchase by CRO
Model No.NomenclatureGenotype
4236 B6.129S2-Nos2tm1MrI N12Inquire for genotype
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Overview

Nomenclature: B6.129S2-Nos2tm1MrI N12

The inducible form of nitric oxide synthase (iNOS or Nos2) plays a key role in the host defense of mammals to infectious agents and tumors. Nos2 deficient mice fail to restrain the replication of Listeria monocytogenes, Mycobacterium tuberculosis, Ectromelia virus, Coxsackie virus, and Leishmania major. Macrophages from these mice show impaired suppression of tumor cells in vitro. The mice also show some protection from endotoxic shock, but many parameters of this disease process are unaffected, suggesting a critical role for other inflammatory mediators.

Origin

This knockout line was produced as a joint collaboration between Drs. Carl Nathan and John MacMicking at Cornell University Medical College and Dr. John Mudgett at Merck Research Laboratories. The line was generated by deleting the first 4 exons and part of the promoter region of the Nos2 gene through gene targeting in 129S7-derived AB2.1 ES cells.

This model is cryopreserved and available for recovery. Models can typically be recovered and delivered to customers within 14-16 weeks after order receipt. Purchase of this model includes perpetual use rights and a deliverable of four mutant animals at the Murine Pathogen Free™ health standard along with a genotyping protocol. For models which include a recombinase gene or multiple alleles, all alleles will be provided, but individual animals may not contain all mutant alleles.

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Genetics

Species:Mouse

Guides & Publications

Initial Publication: MacMicking JD, Nathan C, Hom G, Chartrain N, Fletcher DS, Trumbauer M, Stevens K, Xie QW, Sokol K, Hutchinson N, et al; Altered responses to bacterial infection and endotoxic shock in mice lacking inducible nitric oxide synthase; Cell 1995 May 19;81(4):641-50

Applications & Therapeutic Areas

  • Immunology
  • Inflammation

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Get your Taconic Biosciences 2024 Pricing Guide today. Personalized, customizable, links to up-to-date health reports, and additional information on Taconic's products and services.