| Model No. | Nomenclature | Genotype |
|---|---|---|
| 4236 | B6.129S2-Nos2tm1MrI N12 | Inquire for genotype |
Nos2 Knockout
View:
Select One
- Description
- Price & Licensing
- Overview
- Genetics
- Guides & Publications
- Applications & Therapeutic Areas
- Transit, Housing & Welfare
Overview
Nomenclature: B6.129S2-Nos2tm1MrI N12
The inducible form of nitric oxide synthase (iNOS or Nos2) plays a key role in the host defense of mammals to infectious agents and tumors. Nos2 deficient mice fail to restrain the replication of Listeria monocytogenes, Mycobacterium tuberculosis, Ectromelia virus, Coxsackie virus, and Leishmania major. Macrophages from these mice show impaired suppression of tumor cells in vitro. The mice also show some protection from endotoxic shock, but many parameters of this disease process are unaffected, suggesting a critical role for other inflammatory mediators.
Origin
This model is cryopreserved and available for recovery. Models can typically be recovered and delivered to customers within 14-16 weeks after order receipt. Purchase of this model includes perpetual use rights and a deliverable of four mutant animals at the Murine Pathogen Free™ health standard along with a genotyping protocol. For models which include a recombinase gene or multiple alleles, all alleles will be provided, but individual animals may not contain all mutant alleles.
Taconic’s Colony Management experts can design a plan to grow your colony faster.
Genetics
Guides & Publications
Initial Publication: MacMicking JD, Nathan C, Hom G, Chartrain N, Fletcher DS, Trumbauer M, Stevens K, Xie QW, Sokol K, Hutchinson N, et al; Altered responses to bacterial infection and endotoxic shock in mice lacking inducible nitric oxide synthase; Cell 1995 May 19;81(4):641-50
Applications & Therapeutic Areas
- Immunology
- Inflammation
Transit, Housing & Welfare
Need more info? Click the live chat button or Contact Us
- Select my Health Standard
- Get Custom Pricing Guide
Select my Health Standard
Need help choosing the right Taconic Biosciences health standard for your research?
Use the Health Standard Selector to enter your exclusion list. The tool will tell you which health standards meet your requirements.
Get custom pricing guide
Schedule A Scientific Consultation
Speak with a PhD-level Field Application Scientist who can help you select the most appropriate model and maximize your experimental success.
