| Model No. | Nomenclature | Genotype |
|---|---|---|
| 13917 | Inquire for genotype | Inquire for genotype |
Notch1 - Model 13917 - PM
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Overview
- The targeting vector has been generated using C57BL/6J DNA and transfected into TaconicArtemis C57BL/6NTac ES cell line.
- The targeting strategy allows the generation of a constitutive humanization of a regulatory element of the Notch1 gene.
- The targeting strategy is based on the NCBI transcripts NM_008714.3 (mouse) and NM_017617.3 (human).
- A 10 kb mouse genomic sequence located 5 kb upstream of exon 1 (position on chromosome 2: 26,508,823-26,518,822) will be replaced with its human counterpart (position on chromosome 9: 139,445,239-139,455,238).
- The positive selection marker (Puromycin resistance - PuroR) has been flanked by F3 sites and inserted upstream of the 10 kb region. This cassette also contains a loxP site.
- The humanized allele is obtained after in vitro Flp-mediated removal of the selection markers.
- The remaining recombination site will be located in a non-conserved region of the genome.
- Datamining and Design performed 2013.
Source: TaconicArtemis
This model is cryopreserved and available for recovery. Models can typically be recovered and delivered to customers within 12 weeks after order receipt. Purchase of this model includes perpetual use rights and a deliverable of four mutant animals at the Murine Pathogen Free™ health standard along with a genotyping protocol. For models which include a recombinase gene or multiple alleles, all alleles will be provided, but individual animals may not contain all mutant alleles.
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Notch1 - Model 13917 - PM
Customers may purchase this model by signing the appropriate Terms of Sale (below) and providing a PO.
The GEM Collection Commercial and Academic/Non-Profit Terms of Sale grant perpetual use rights.
| Item | Commercial | Nonprofit |
| Cryopreserved Model | $32,500 | $5,500 |
| Item | Commercial | Nonprofit |
| Cryopreserved Model | €29.500 | €5.005 |
Cryopreserved models are invoiced upon shipment of recovered animals. Once orders are placed, the full purchase price will be applied if the order is canceled. For orders greater than 4 animals, please contact Taconic for options.
Fees for Taconic Transit Cages™ and freight are in addition to the price above.
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