Prmt2 - Model 7915 - KO

  • Cryopreserved
  • Mouse
  • Not available for direct purchase by CRO
  • GEM Collection
Model No.NomenclatureGenotype
7915C57BL/6-Prmt2tm1.2 MrlInquire for genotype
View:
Select One

Overview

Nomenclature: C57BL/6-Prmt2tm1.2 Mrl

  • The targeting vector has been generated using C57BL/6J DNA and transfected into C57BL/6NTac ES cell line.
  • Prmt2 exon 2 contains the translation initiation codon.
  • Exon 5 has been flanked by loxP sites and contains the mutation residues 145-149 GCGTG to AAAAA.
  • The constitutive KO allele has been generated after Cre-mediated recombination by crossing chimeras to a Cre-Deleter on a C57BL/6 background.
  • The constitutive KO line has been subsequently backcrossed to C57BL/6NTac animals for at least 2 generations and the Cre-transgene was removed by segregation.
  • Deletion of exon 5 should result in loss of function of the Prmt2 by deleting part of the SAM_bd domain.
  • The remaining recombination sites are located in intron regions of the genome.
  • Data mining and Design performed in 2006.

Source: Mouse Clinical Institute (MCI)

This model is cryopreserved and available for recovery. Models can typically be recovered and delivered to customers within 14-16 weeks after order receipt. Purchase of this model includes perpetual use rights and a deliverable of four mutant animals at the Murine Pathogen Free™ health standard along with a genotyping protocol. For models which include a recombinase gene or multiple alleles, all alleles will be provided, but individual animals may not contain all mutant alleles.

Taconic’s Colony Management experts can design a plan to grow your colony faster.

Genetics

Species:Mouse
Strain Type:Inbred
Allele Type:Constitutive Knockout
Genetic Background:C57BL/6
Gene Family: Transferase
Gene Symbol: Prmt2
Gene Accession Number: NM_133182
Gene Name: protein arginine N-methyltransferase 2

7915 WT

0091 cKO

7915 KO

key-allele.jpg

Guides & Publications

Transit, Housing & Welfare

Need more info? Click the live chat button or Contact Us

Prmt2 - Model 7915 - KO

Customers may purchase this model by signing the appropriate Terms of Sale (below) and providing a PO.

The GEM Collection Commercial and Academic/Non-Profit Terms of Sale grant perpetual use rights.

    ItemCommercialNonprofit
    Cryopreserved Model$32,500$5,500
      ItemCommercialNonprofit
      Cryopreserved Model€29.500€5.005

       

      Cryopreserved models are invoiced upon shipment of recovered animals. Once orders are placed, the full purchase price will be applied if the order is canceled. For orders greater than 4 animals, please contact Taconic for options.

      Fees for Taconic Transit Cages™ and freight are in addition to the price above.

       

      Select my Health Standard

      Need help choosing the right Taconic Biosciences health standard for your research?

      Use the Health Standard Selector to enter your exclusion list. The tool will tell you which health standards meet your requirements.

      Get custom pricing guide

      2024 Pricing Guide Now Available

      Get your Taconic Biosciences 2024 Pricing Guide today. Personalized, customizable, links to up-to-date health reports, and additional information on Taconic's products and services.

      Schedule A Scientific Consultation

      Speak with a PhD-level Field Application Scientist who can help you select the most appropriate model and maximize your experimental success.

      Want to Get in Touch?

      Chat with us or reach out to our global team

      phone

      2024 Pricing Guide Now Available

      Get your Taconic Biosciences 2024 Pricing Guide today. Personalized, customizable, links to up-to-date health reports, and additional information on Taconic's products and services.