| Model No. | Nomenclature | Genotype |
|---|---|---|
| 14092 | B6.Cg-Tg(Prox1-cre/ERT2)1Tmak | Inquire for genotype |
Prox1-CreERT2 Mouse
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- Overview
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Overview
Nomenclature: B6.Cg-Tg(Prox1-cre/ERT2)1Tmak
- An inducible cre deleter under the control of the prospero homeobox 1 (Prox1) promoter.
- Cre recombination is inducible via administration of tamoxifen.
- Allows specific and temporally controlled cre-loxP recombination (gene inactivation/activation) in Prox1-expressing tissues, including lymphatic endothelia.
- Efficient recombination is observed during all developmental stages (embryonic, postnatal) and in adults.
Origin
The Prxo1-creERT2 mouse was developed in the laboratory of Taija Makinen at the London Research Institute. A cDNA encoding tamoxifen inducible Cre recombinase (CreERT2) followed by SV40 polyadenylation signal was introduced into the start codon of Prox1 in BAC clone RP23-190F21 using homologous recombination in bacteria. Founder lines were backcrossed to C57BL/6. Taconic received embryos from CRT in 2015.
This model is cryopreserved and available for recovery. Models can typically be recovered and delivered to customers within 14-16 weeks after order receipt. Purchase of this model includes perpetual use rights and a deliverable of four mutant animals at the Murine Pathogen Free™ health standard along with a genotyping protocol. For models which include a recombinase gene or multiple alleles, all alleles will be provided, but individual animals may not contain all mutant alleles.
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Genetics
Guides & Publications
Initial Publication:
Bazigou et al. 2011. Genes regulating lymphangiogenesis control venous valve formation and maintenance in mice. J Clin Invest. Aug 1; 121(8): 2984–2992.
Applications & Therapeutic Areas
- Oncology & Immuno-Oncology
- Recombinase-mediated Gene Deletion
Transit, Housing & Welfare
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- Licensing
- Pricing - USD
- Pricing - EUR
- Select my Health Standard
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Prox1-CreERT2 Mouse
Customers may purchase this model by signing the appropriate Terms of Sale (below) and providing a PO.
This model is sold under terms which grant perpetual use rights.
This model is sold under terms which grant perpetual use rights.
Pricing - USD
14092
| Item | Commercial | Nonprofit |
|---|---|---|
| Cryopreserved Model | $36,750.00 | $14,700.00 |
Cryopreserved models are invoiced upon shipment of recovered animals. Once orders are placed, the full purchase price will be applied if the order is canceled. For orders greater than 4 animals, please contact Taconic for options.
Fees for Taconic Transit Cages™ and freight are in addition to the price above.
Pricing - EUR
14092
| Item | Commercial | Nonprofit |
|---|---|---|
| Cryopreserved Model | €33.390,00 | €13.125,00 |
Cryopreserved models are invoiced upon shipment of recovered animals. Once orders are placed, the full purchase price will be applied if the order is canceled. For orders greater than 4 animals, please contact Taconic for options.
Fees for Taconic Transit Cages™ and freight are in addition to the price above.
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