| Model No. | Nomenclature | Genotype |
|---|---|---|
| TGAC | FVB/NTac-Tg(Hba-x-v-Ha-ras)TG.ACLed | tg/wt |
v-Ha-ras
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Overview
Nomenclature: FVB/NTac-Tg(Hba-x-v-Ha-ras)TG.ACLed
- Carries the activated v-Ha-ras oncogene fused to a mouse zeta-globin promoter
- Exhibits characteristics of genetically initiated skin as a target for tumorigenesis, with a predisposition to papillomas
- Useful in rapid screening of tumor promoters, non-genotoxic carcinogens and for assessing anti-tumor and anti-proliferative agents
- Hemizygous TG.AC mice are under evaluation as alternatives to the 2-year carcinogenicity bioassay
Availability
Occasionally, it becomes necessary to discontinue live production of Taconic Transgenic Models™ due to lack of interest. The v-Ha-ras mouse is one such model. Live production of this model ended in 2011. If you have a need for this model, please contact us to discuss available options.Origin
This model is cryopreserved and available for recovery. Models can typically be recovered and delivered to customers within 12 weeks after order receipt. Purchase of this model includes perpetual use rights and a deliverable of four mutant animals at the Murine Pathogen Free™ health standard along with a genotyping protocol. For models which include a recombinase gene or multiple alleles, all alleles will be provided, but individual animals may not contain all mutant alleles.
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Genetics
Guides & Publications
Initial Publication: Leder A, Kuo A, Cardiff RD, Sinn E, Leder P. (1990) v-Ha-ras Transgene Abrogates the Initiation Step in Mouse Skin Tumorigenesis: Effects of Phorbol Esters and Retinoic Acid. Proc Natl Acad Sci USA, 87:9178-82.
Applications & Therapeutic Areas
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Licensing
Conditions of Use for Taconic Transgenic Models™
Taconic Transgenic Models™ (Models) are produced and distributed under rights to patents and intellectual property licensed from various institutions. Taconic sells the Models to purchasers, grants to each purchaser a right under Taconic's rights in such licensed patents and intellectual property to use the purchased Model in consideration of purchasers' acknowledgement of and agreement to the Terms and Conditions for Taconic Models, Products and Services and the following terms of use:
- Title to these Models and biological materials derived from them remains with Taconic.
- The Models will be used for research purposes only.
- The Models will not be bred or cross-bred except to obtain embryos or fetuses required for research purposes unless additional rights have been granted in writing by Taconic.
- The Models and biological materials derived from them will not be distributed to third parties or used for commercial purposes.
- Non-profit purchasers may not use this Model and/or biological materials derived from it in sponsored research or contract research studies unless it is purchased at the for-profit price.
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