Model No. | Nomenclature | Genotype |
---|---|---|
3715-F | B6.SJL-Tg(APOA-CETP)1Dsg N11 | tg/wt |
3715-M | B6.SJL-Tg(APOA-CETP)1Dsg N11 | tg/wt |
Model No. | Nomenclature | Genotype |
---|---|---|
3715-F | B6.SJL-Tg(APOA-CETP)1Dsg N11 | tg/wt |
3715-M | B6.SJL-Tg(APOA-CETP)1Dsg N11 | tg/wt |
Nomenclature: B6.SJL-Tg(APOA-CETP)1Dsg N11
Origin
The CETP mouse was developed in the laboratory of Dr. David Grass at Xenogen Biosciences, now Taconic. The model was created by microinjecting the human CETP gene into (C57BL/6J x SJL) F2 zygotes. Taconic received stock in April 1996 at the second backcross from the founder line. The mice were then backcrossed one generation to C57BL/6 prior to intercrossing for homozygosity. Backcrossing to C57BL/6NTac recommenced at Taconic in 2004. The line was backcrossed a total of 10 generations (N10) and then intercrossed to homozygosity. A homozygous colony is maintained for the production of hemizygotes through mating to C57BL/6NTac (N11).
Initial Publication:
Grass, D.S., Saini, U., Felkner, R.H., Wallace, R.E., Lago, W.J.P., Young, S.G., Swanson, M.E. (1995). Transgenic Mice expressing both human apolipoprotein B and human CETP have a lipoprotein cholesterol distribution similar to that of normolipidemic humans. The Journal of Lipid Research, Vol. 36, No. 5, pp. 1082-1090.
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Packing Practices
Taconic standard practice is to recombine animals of different home cages and/or ages from a single model and sex during packing, except in specific cases where Taconic's animal welfare policy prohibits recombination due to aggression or other concerns. When an order is fulfilled with animals from more than one week of birth, this standard practice results in animals from a range of birth weeks packed together in a single TTC. When an order is fulfilled with animals from genotyped models, this standard practice results in animals from different home cages packed together in a single TTC.
Customers who wish to keep animals from different weeks of birth separated should place orders with the special instruction "Divide and label by age." Note that this special request can result in increased costs for additional Taconic Transit Cages, dividers and/or freight charges.
Taconic discourages other types of custom packing requests as they can have a negative impact on animal welfare. Learn more.
Conditions of Use for Taconic Transgenic Models™
Taconic Transgenic Models™ (Models) are produced and distributed under rights to patents and intellectual property licensed from various institutions. Taconic sells the Models to purchasers, grants to each purchaser a right under Taconic's rights in such licensed patents and intellectual property to use the purchased Model in consideration of purchasers' acknowledgement of and agreement to the Terms and Conditions for Taconic Models, Products and Services and the following terms of use:
Age in Weeks | Quantity 1 - 999 |
3 to 10 | $425.00 |
Age in Weeks | Quantity 1 - 999 |
3 to 10 | $425.00 |
Age in Weeks | Quantity 1 - 999 |
3 to 10 | €387,00 |
Age in Weeks | Quantity 1 - 999 |
3 to 10 | €387,00 |
Age in Weeks | Quantity 1 - 999 |
3 to 10 | $375.00 |
Age in Weeks | Quantity 1 - 999 |
3 to 10 | $375.00 |
Age in Weeks | Quantity 1 - 999 |
3 to 10 | €341,00 |
Age in Weeks | Quantity 1 - 999 |
3 to 10 | €341,00 |
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