Nomenclature: B6;C3-Tg(CAG-DPP4)52Ctkt

• Mice expressing human DPP4 are susceptible to infection by MERS-CoV, the virus that causes Middle East respiratory syndrome coronavirus. The hDPP4 mouse model expresses human DPP4 cDNA under the control of the CAG promoter.
• Published reports indicate that the hDPP4 mouse develops disseminated, fatal disease upon infection with MERS-CoV at higher viral doses
• This model is useful for study of MERS disease pathogenesis, treatment and vaccines
• This model may also be useful to test pan-coronavirus vaccines
• The genetic background of this model will change over time as it will be continually backcrossed to C57BL/6NTac. Wild type (wt/wt) mice from the 18517 colony are the recommended wild type control at this time.
• Distribution of this model is subsidized by CEPI

Orders by weight: Taconic cannot accept orders by weight for this model. Please note that shipments may contain animals with a larger weight variation. 

Origin

The hDPP4 Mouse was generated in the laboratory of Chien-Te (Kent) Tseng at University of Texas Medical Branch (UTMB) in Galveston.  The transgene, comprising CAGG enhancer/promoter, intron sequence, human DPP4 cDNA, and rabbit beta globin poly(A) signal was injected into B6C3F1/J x C57BL/6J zygotes. Taconic maintains the line by mating hemizygous hDPP4 mice to C57BL/6NTac wild type mice.