| Model No. | Nomenclature | Genotype |
|---|---|---|
| 18517-F | B6;C3-Tg(CAG-DPP4)52Ctkt | tg/wt |
| 18517-M | B6;C3-Tg(CAG-DPP4)52Ctkt | tg/wt |
| 18517-F | B6;C3-Tg(CAG-DPP4)52Ctkt | wt/wt |
| 18517-M | B6;C3-Tg(CAG-DPP4)52Ctkt | wt/wt |
hDPP4
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Overview
Nomenclature: B6;C3-Tg(CAG-DPP4)52Ctkt
- Mice expressing human DPP4 are susceptible to infection by MERS-CoV, the virus that causes Middle East respiratory syndrome coronavirus. The hDPP4 mouse model expresses human DPP4 cDNA under the control of the CAG promoter.
- Published reports indicate that the hDPP4 mouse develops disseminated, fatal disease upon infection with MERS-CoV at higher viral doses
- This model is useful for study of MERS disease pathogenesis, treatment and vaccines
- This model may also be useful to test pan-coronavirus vaccines
- The genetic background of this model will change over time as it will be continually backcrossed to C57BL/6NTac. Wild type (wt/wt) mice from the 18517 colony are the recommended wild type control at this time.
- Distribution of this model is subsidized by CEPI
Orders by weight: Taconic cannot accept orders by weight for this model. Please note that shipments may contain animals with a larger weight variation.
Origin
The hDPP4 Mouse was generated in the laboratory of Chien-Te (Kent) Tseng at University of Texas Medical Branch (UTMB) in Galveston. The transgene, comprising CAGG enhancer/promoter, intron sequence, human DPP4 cDNA, and rabbit beta globin poly(A) signal was injected into B6C3F1/J x C57BL/6J zygotes. Taconic maintains the line by mating hemizygous hDPP4 mice to C57BL/6NTac wild type mice.
Genetics
Guides & Publications
Agrawal AS, Garron T, Tao X, Peng BH, Wakamiya M, Chan TS, Couch RB, Tseng CT. Generation of a transgenic mouse model of Middle East respiratory syndrome coronavirus infection and disease. J Virol. 2015 Apr;89(7):3659-70. doi: 10.1128/JVI.03427-14. Epub 2015 Jan 14. PMID: 25589660; PMCID: PMC4403411.
Applications & Therapeutic Areas
- Infectious disease
- Vaccine research
Transit, Housing & Welfare
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Diet
Data
The hDPP4 Mouse can be used to assess MERS therapeutics
Fig 1. hDPP4 mice were infected with 104 TCID50 of MERS-CoV and then treated 12 h later with either therapeutic antibody m336 or a control antibody m102.4. Mice were monitored daily for A) bodyweight change and B) morbidity and mortality.
Figure adapted from Agrawal, A., Ying, T., Tao, X. et al. Passive Transfer of A Germline-like Neutralizing Human Monoclonal Antibody Protects Transgenic Mice Against Lethal Middle East Respiratory Syndrome Coronavirus Infection. Sci Rep 6, 31629 (2016). https://doi.org/10.1038/srep31629 . Licensed under CC BY 4.0 (https://creativecommons.org/licenses/by/4.0/).
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Licensing
Conditions of Use for Taconic Transgenic Models™
Taconic Transgenic Models™ (Models) are produced and distributed under rights to patents and intellectual property licensed from various institutions. Taconic sells the Models to purchasers, grants to each purchaser a right under Taconic's rights in such licensed patents and intellectual property to use the purchased Model in consideration of purchasers' acknowledgement of and agreement to the Terms and Conditions for Taconic Models, Products and Services and the following terms of use:
- Title to these Models and biological materials derived from them remains with Taconic.
- The Models will be used for research purposes only.
- The Models will not be bred or cross-bred except to obtain embryos or fetuses required for research purposes unless additional rights have been granted in writing by Taconic.
- The Models and biological materials derived from them will not be distributed to third parties or used for commercial purposes.
- Non-profit purchasers may not use this Model and/or biological materials derived from it in sponsored research or contract research studies unless it is purchased at the for-profit price.
Pricing - USD
Murine Pathogen Free (MPF) Health Standard
18517 Female
18517-F Genotype tg/wt
| Age in Weeks | Quantity 1 - 999 |
| 4 to 10 | $285.00 |
18517-F Genotype wt/wt
| Age in Weeks | Quantity 1 - 999 |
| 4 to 10 | $200.00 |
18517 Male
18517-M Genotype tg/wt
| Age in Weeks | Quantity 1 - 999 |
| 4 to 10 | $285.00 |
18517-M Genotype wt/wt
| Age in Weeks | Quantity 1 - 999 |
| 4 to 10 | $200.00 |
Pricing - EUR
Murine Pathogen Free (MPF) Health Standard
18517 Female
18517-F Genotype tg/wt
| Age in Weeks | Quantity 1 - 999 |
| 4 to 10 | €256,00 |
18517-F Genotype wt/wt
| Age in Weeks | Quantity 1 - 999 |
| 4 to 10 | €180,00 |
18517 Male
18517-M Genotype tg/wt
| Age in Weeks | Quantity 1 - 999 |
| 4 to 10 | €256,00 |
18517-M Genotype wt/wt
| Age in Weeks | Quantity 1 - 999 |
| 4 to 10 | €180,00 |
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