| Model No. | Nomenclature | Genotype |
|---|---|---|
| 11026-F | C57BL/6- Del(16Dgcr2-Hira)1Tac | ko/wt |
| 11026-M | C57BL/6- Del(16Dgcr2-Hira)1Tac | ko/wt |
Human 22q11.2 Deletion [Df(h22q11)/+] Mouse
![Human 22q11.2 deletion [Df(h22q11)/+] mouse](https://assets.taconic.com/is/image/taconic/human-22q11-2-deletion-mouse-1?ts=1695185418418&dpr=off)
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Overview
Nomenclature: C57BL/6- Del(16Dgcr2-Hira)1Tac
- Carries a genomic deletion of a region of mouse chromosome 16 that corresponds to human chromosome region 22q11.2.
- In humans, hemizygous deletion of chromosome 22q11.2 confers high risk of neurodevelopmental disorders, including autism and schizophrenia, with up to 41% of deletion carriers experiencing psychotic symptoms.
- Df(h22q11)/+] mice have reduced prepulse inhibition (PPI) and increased acoustic startle response (ASR).
- Increased NMDAR antagonist-induced locomotion: show increased activity in response to PCP- and ketamine-induced locomotor activity in postpubertal mice.
- Increased 3,4-Dihydroxyphenylacetic acid (DOPAC) levels in the pre-frontal cortex.
- Displays phenotype characteristic of narrow palpebral fissures (small eyes).
- Useful as a model of schizophrenia-like pathology and for studying the underlying biology of schizophrenia and other psychiatric disorders related to 22q11.2 deletion in humans.
Availability
Available off-the shelfOrigin
Genetics
Guides & Publications
Initial Publication: Didriksen M, Fejgin K, Nilsson SR, Birknow MR, Grayton HM, Larsen PH, Lauridsen JB, Nielsen V, Celada P, Santana N, Kallunki P, Christensen KV, Werge TM, Stensbøl TB, Egebjerg J, Gastambide F, Artigas F, Bastlund JF, Nielsen J. (2016) Persistent gating deficit and increased sensitivity to NMDA receptor antagonism after puberty in a new mouse model of the human 22q11.2 microdeletion syndrome: a study in male mice. J Psychiatry Neurosci. 2016 Jul 7;41(5):150381.
Applications & Therapeutic Areas
- Neuroscience
- Psychiatric Disorders
Transit, Housing & Welfare
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Packing Practices
Taconic standard practice is to recombine animals of different home cages and/or ages from a single model and sex during packing, except in specific cases where Taconic's animal welfare policy prohibits recombination due to aggression or other concerns. When an order is fulfilled with animals from more than one week of birth, this standard practice results in animals from a range of birth weeks packed together in a single TTC. When an order is fulfilled with animals from genotyped models, this standard practice results in animals from different home cages packed together in a single TTC.
Customers who wish to keep animals from different weeks of birth separated should place orders with the special instruction "Divide and label by age." Note that this special request can result in increased costs for additional Taconic Transit Cages, dividers and/or freight charges.
Taconic discourages other types of custom packing requests as they can have a negative impact on animal welfare. Learn more.
Diet
- Licensing
- Pricing - USD
- Pricing - EUR
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Human 22q11.2 Deletion [Df(h22q11)/+] Mouse
Conditions of Use for Taconic Transgenic Models™
Taconic Transgenic Models™ (Models) are produced and distributed under rights to patents and intellectual property licensed from various institutions. Taconic sells the Models to purchasers, grants to each purchaser a right under Taconic's rights in such licensed patents and intellectual property to use the purchased Model in consideration of purchasers' acknowledgement of and agreement to the Terms and Conditions for Taconic Models, Products and Services and the following terms of use:
- Title to these Models and biological materials derived from them remains with Taconic.
- The Models will be used for research purposes only.
- The Models will not be bred or cross-bred except to obtain embryos or fetuses required for research purposes unless additional rights have been granted in writing by Taconic.
- The Models and biological materials derived from them will not be distributed to third parties or used for commercial purposes.
- Non-profit purchasers may not use this Model and/or biological materials derived from it in sponsored research or contract research studies unless it is purchased at the for-profit price.
Pricing - USD
Murine Pathogen Free (MPF) Health Standard
11026 Female
11026-F Genotype ko/wt
| Age in Weeks | Quantity 1 - 999 |
| 4 to 10 | $521.00 |
11026 Male
11026-M Genotype ko/wt
| Age in Weeks | Quantity 1 - 999 |
| 4 to 10 | $521.00 |
Pricing - EUR
Murine Pathogen Free (MPF) Health Standard
11026 Female
11026-F Genotype ko/wt
| Age in Weeks | Quantity 1 - 999 |
| 4 to 10 | €476,00 |
11026 Male
11026-M Genotype ko/wt
| Age in Weeks | Quantity 1 - 999 |
| 4 to 10 | €476,00 |
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