Model No. | Nomenclature | Genotype |
---|---|---|
MDR1A-F | FVB.129P2-Abcb1atm1Bor N7 | ko/ko |
MDR1A-M | FVB.129P2-Abcb1atm1Bor N7 | ko/ko |
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For additional information on other Taconic Notices and Polices please visit the pages below.
Model No. | Nomenclature | Genotype |
---|---|---|
MDR1A-F | FVB.129P2-Abcb1atm1Bor N7 | ko/ko |
MDR1A-M | FVB.129P2-Abcb1atm1Bor N7 | ko/ko |
There have been several reports of colitis phenotype expression issues for this product. This product is currently not recommended for colitis research while we investigate the reported issues. Please reach out to scisupport@taconic.com for help choosing an appropriate colitis model for your research.
Visit the Terms and Conditions page for important information on Definitions, Conditions of Use, Limited Warranty for MODELS, PRODUCTS or SERVICES, Standards of Animal Care and other pertinent information.
*Special licensing terms that apply to individual products are listed in the "Price & Licensing" section of the product page.
For additional information on other Taconic Notices and Polices please visit the pages below.
Nomenclature: FVB.129P2-Abcb1atm1Bor N7
Origin
The Mdr1a mouse was developed in the laboratory of Alfred Schinkel of the Netherlands Cancer Institute. The model was created by targeting the Abcb1a gene in E14 ES cells. Resultant chimeras were backcrossed to FVB for seven (N7) generations. Taconic received stock in 1994 and derived the line by Caesarean transfer. The colony is maintained by incrossing homozygous mice.
Species:Mouse
Strain Type:Congenic
Allele Type:Constitutive Knockout
Coat Color:Albino
Genetic Background:FVB
Other Genetic Notes:
Wildtype for Nnt mutation; carries Pde6brd1 mutation
Initial Publication:
Schinkel AH, Smit JJM, van Tellingen O, Beijnen JH, Wagenaar E, van Deetmer L, Mol CAAM, van der Valk MA, Robanus-Maandag BC, te Tiele HPJ, Berns AJM, Borst P. (1994) Disruption of the Mouse mdr1a P-Glycoprotein Gene Leads to a Deficiency in the Blood Brain Barrier and to Increased Sensitivity to Drugs. Cell, 77:491-502.
Transit, Housing & Welfare
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Packing Practices
Taconic standard practice is to recombine animals of different home cages and/or ages from a single model and sex during packing, except in specific cases where Taconic's animal welfare policy prohibits recombination due to aggression or other concerns. When an order is fulfilled with animals from more than one week of birth, this standard practice results in animals from a range of birth weeks packed together in a single TTC. When an order is fulfilled with animals from genotyped models, this standard practice results in animals from different home cages packed together in a single TTC.
Customers who wish to keep animals from different weeks of birth separated should place orders with the special instruction "Divide and label by age." Note that this special request can result in increased costs for additional Taconic Transit Cages, dividers and/or freight charges.
Taconic discourages other types of custom packing requests as they can have a negative impact on animal welfare. Learn more.
Conditions of Use for Taconic Transgenic Models™
Taconic Transgenic Models™ (Models) are produced and distributed under rights to patents and intellectual property licensed from various institutions. Taconic sells the Models to purchasers, grants to each purchaser a right under Taconic's rights in such licensed patents and intellectual property to use the purchased Model in consideration of purchasers' acknowledgement of and agreement to the Terms and Conditions for Taconic Models, Products and Services and the following terms of use:
Age in Weeks | Quantity 1 - 999 |
---|---|
3 to 10 | $ 417.00 |
MDR1A-RF Genotype ko/ko | Quantity 1 - 199 |
---|---|
Retired Female Breeder | $ 417.00 |
Age in Weeks | Quantity 1 - 999 |
---|---|
3 to 10 | $ 417.00 |
MDR1A-RM Genotype ko/ko | Quantity 1 - 199 |
---|---|
Retired Male Breeder | $ 417.00 |
Age in Weeks | Quantity 1 - 999 |
---|---|
3 to 10 | 379,00 € |
MDR1A-RF Genotype ko/ko | Quantity 1 - 199 |
---|---|
Retired Female Breeder | 379,00 € |
Age in Weeks | Quantity 1 - 999 |
---|---|
3 to 10 | 379,00 € |
MDR1A-RM Genotype ko/ko | Quantity 1 - 199 |
---|---|
Retired Male Breeder | 379,00 € |
Age in Weeks | Quantity 1 - 999 |
---|---|
3 to 10 | $ 292.00 |
MDR1A-RF Genotype ko/ko | Quantity 1 - 199 |
---|---|
Retired Female Breeder | $ 292.00 |
Age in Weeks | Quantity 1 - 999 |
---|---|
3 to 10 | $ 292.00 |
MDR1A-RM Genotype ko/ko | Quantity 1 - 199 |
---|---|
Retired Male Breeder | $ 292.00 |
Age in Weeks | Quantity 1 - 999 |
---|---|
3 to 10 | 266,00 € |
MDR1A-RF Genotype ko/ko | Quantity 1 - 199 |
---|---|
Retired Female Breeder | 266,00 € |
Age in Weeks | Quantity 1 - 999 |
---|---|
3 to 10 | 266,00 € |
MDR1A-RM Genotype ko/ko | Quantity 1 - 199 |
---|---|
Retired Male Breeder | 266,00 € |
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