Mdr1a

Mdr1a Constitutive Knockout Mouse Model
  • Live
  • Mouse
  • Male & Female Available
  • Albino
  • Available for direct purchase by CRO
Model No.NomenclatureGenotype
MDR1A-F FVB.129P2-Abcb1atm1Bor N7ko/ko
MDR1A-M FVB.129P2-Abcb1atm1Bor N7ko/ko
View:
Select One

Overview

Nomenclature: FVB.129P2-Abcb1atm1Bor N7

 

  • Carries a disruption of multi-drug resistance genes Abcb1a (ATP-binding cassette, sub-family B (MDR/TAP), member 1A, a.k.a. Mdr1a) encoding p-glycoprotein 3
  • Mdr1a protein is expressed actively in the intestine and at the blood-brain and blood-testis barriers
  • p-glycoprotein 3 actively extrudes a wide range of drugs from cells and can confer multi-drug resistance to tumor cells
  • Lack the protective function of p-glycoprotein 3 and exhibits a functional deficiency in the blood-brain barrier
  • Useful in neurotoxicology, drug transport, chemotherapy, multi-drug resistance and oral bioavailability research
  • Susceptible to developing a severe, spontaneous intestinal inflammation phenotypically similiar to human inflammatory bowel disease (IBD)
Orders by weight: Taconic cannot accept orders by weight for this model. Please note that shipments may contain animals with a larger weight variation.

Origin

The Mdr1a mouse was developed in the laboratory of Alfred Schinkel of the Netherlands Cancer Institute. The model was created by targeting the Abcb1a gene in E14 ES cells. Resultant chimeras were backcrossed to FVB for seven (N7) generations. Taconic received stock in 1994 and derived the line by Caesarean transfer. The colony is maintained by incrossing homozygous mice.

Schedule A Scientific Consultation

Speak with a PhD-level Field Application Scientist who can help you select the most appropriate model and maximize your experimental success.

Want to Get in Touch?

Chat with us or reach out to our global team

phone

Webinar On-Demand

ON-DEMAND WEBINAR | Validated Il10 Knockout Models for IBD Research

Webinar On-Demand

ON-DEMAND WEBINAR | Genetically Engineered Mouse Colitis Models for Preclinical Drug Development

2025 Pricing Guide Now Available

Get your Taconic Biosciences 2025 Pricing Guide today. Personalized, customizable, links to up-to-date health reports, and additional information on Taconic's products and services.

Pricing Guide