Transgenic HLA Models

Taconic Biosciences offers an exclusive portfolio of transgenic rodents which express human HLA molecules. 

Transgenic mice that express chimeric human HLA molecules represent a unique in vivo experimental model for evaluating human immune system function. The comprehensive Taconic Transgenic HLA model portfolio provides excellent coverage across HLA class I supertypes as well as an exclusive HLA class II supertype model, which are all available under simple use terms without license fees.

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The Importance of Chimeric HLA Molecules

Taconic HLA mice express human HLA domains to ensure HLA-restricted antigen presentation while murine MHC domains result in efficient binding to murine CD4/8 and subsequent downstream T cell activation. 

Key Applications of the Transgenic HLA Models:

  • Vaccine research
  • Immuno-oncology
  • Autoimmune Disease
  • Infectious Diseases and Bioterror Agents

HLA Models available exclusively from Taconic: