| Model No. | Nomenclature | Genotype |
|---|---|---|
| huPBMC-NOG-F | NOD.Cg-Prkdcscid Il2rgtm1Sug/JicTac | sp/sp;ko/ko |
| huPBMC-NOG-M | NOD.Cg-Prkdcscid Il2rgtm1Sug/JicTac | sp/sp;ko/y |
huPBMC-NOG
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Overview
Nomenclature: NOD.Cg-Prkdcscid Il2rgtm1Sug/JicTac
- huPBMC-NOG is a model for investigation of adult/mature cell populations.
- This model permits the assessment of effector and memory T cells.
- Human peripheral blood mononuclear cell (PBMC) engrafted mice are optimally suited for studies immediately following engraftment as Graft vs. Host Disease (GvHD) limiting survival time to 4-6 weeks. In addition, the GvHD response can be used as a screening system for T cell modulating drugs, with readouts including body weight and clinical condition, liver injury and immune cell infiltration into organs.
- See Søndergaard et al. and Cox et al. for description of the GvHD model and its use in drug target validation.
- By default, Taconic does not typically utilize myeloablation prior to PBMC engraftment as it can shorten the study window. If desired, inquire about options such as irradiation, PBMCs of specific donor HLA types or patient-derived PBMCs.
- We recommend reviewing the comprehensive document Taconic's Humanized Immune System Models: Licensing, Care & Resources and the Video: Care of HIS mice for experimental success prior to ordering.
Read the Related Taconic Biosciences' Insight:Availability
huPBMC-NOG mice are produced upon order and delivered within one week of injections.Genetics
Guides & Publications
Applications & Therapeutic Areas
- Immunology
- Infectious Disease
- Oncology & Immuno-Oncology
- Safety Assessment
- Transgenic Model Generation Support
- Cell and Tissue Humanized
- Inflammation
Transit, Housing & Welfare
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Taconic packs humanized immune system mice as cagemates - one engraftment lot per Taconic Transit Cage (TTC). Taconic does not combine different lots into a single TTC.
Diet
huPBMC NOG Demonstrate Signifcant Engraftment
Figure 1: Human CD45+ cells were enumerated by flow cytometry at daily intervals follow PBMC engraftment. Significant engraftment was observed after 14 days. The majority of human CD45+ cells are CD3+ T cells.
Irradiation Exacerbates GvHD in PBMC-engrafted NOG Mice
Figure 2: Irradiation exacerbates GvHD in PBMC engrafted NOG mice. Survival curves for PBMC engrafted NOG mice at increasing doses of radiation with, or without pre-treatment with anti-TNFa blocking antibody.
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huPBMC-NOG
Nonprofit users (excluding users at nonprofit foundations which are affiliated with a for-profit entity): For internal research purposes, the CIEA NOG mouse® Conditions of Use for nonprofit users apply. If you wish to perform sponsored research or fee-for-service contract research using the CIEA NOG mouse®, please inquire for access conditions.
For-profit users and users at foundations which are affiliated with for-profit entities: The CIEA NOG mouse® Conditions of Use for for-profit users apply.
The CIEA NOG mouse® is produced and distributed under license rights to the following patents and trademarks:
- Japanese Patent No. 3,753,321
- US Patent No. 7,145,055; 5,464,764; 5,487,992; 5,627,059; 5,631,153; 5,789,215; 6,204,061; 6,653,113; 6,689,610
EP Patent No. 1,338,198 - Japanese Trademark Reg. No. 4,823,423
- US Trademark Reg. No. 3,118,040
- EU Trademark Reg. No. 3,736,758
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