| Model No. | Nomenclature | Genotype |
|---|---|---|
| ICRSC-F | IcrTac:ICR-Prkdcscid | sp/sp |
| ICRSC-M | IcrTac:ICR-Prkdcscid | sp/sp |
ICR scid
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Overview
Nomenclature: IcrTac:ICR-Prkdcscid
- Equivalent to C.B-17 scids in severity of immunodeficiency, but this outbred background exhibits a significantly reduced incidence of spontaneous Ig production (leakiness)
- Gains weight faster than the C.B-17 scid which makes the ICR-scid better suited for ascites production from heterohybridomas and as a host for tumor lines
- Mice homozygous for the scid mutation lack both T and B cells due to a defect in V(D)J recombination. They easily accepts foreign tissue transplants, including human tumors, making them effective models for testing new cancer treatments. Scid mice are also useful for examining the relationship between immunity and disease.
Origin
The ICR scid spontaneous mutant model was developed by the Fox Chase Cancer Center by intercrossing ICR mice to C.B-17-SCID mice. The mice were then backcrossed two generations to a Icr:Ha(ICR) outbred background. Taconic received stock in 1992.
Genetics
Guides & Publications
Applications & Therapeutic Areas
- Immunology
- Inflammation
- Oncology & Immuno-Oncology
Transit, Housing & Welfare
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Packing Practices
Taconic standard practice is to recombine animals of different home cages and/or ages from a single model and sex during packing, except in specific cases where Taconic's animal welfare policy prohibits recombination due to aggression or other concerns. When an order is fulfilled with animals from more than one week of birth, this standard practice results in animals from a range of birth weeks packed together in a single TTC. When an order is fulfilled with animals from genotyped models, this standard practice results in animals from different home cages packed together in a single TTC.
Customers who wish to keep animals from different weeks of birth separated should place orders with the special instruction "Divide and label by age." Note that this special request can result in increased costs for additional Taconic Transit Cages, dividers and/or freight charges.
Taconic discourages other types of custom packing requests as they can have a negative impact on animal welfare. Learn more.
Diet
Data
Average litter size: 7
For some applications, weight may be critical. For orders where weight is critical, please place orders by weight, not by age. Taconic can accept orders by weight for this model. For orders sourced from US or Denmark a production minimum 3 gram span is accepted. All weights are weights at time of packing. Mice and rats can lose weight in transit. Orders for specific weight spans will be assessed a nominal fee. More detail on weight order policies is available.
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n= 100 per sex at RF health standards from US colonies. Data collected 2013-15.
High and Low represent mean +/- 2 standard deviation.
Based on sample size the charts above represents ~90% of the population.
All growth curves represent animals housed in our barriers, at our standard density and fed NIH31-M diet. Variations at customer facilities will alter expected growth curves.
Growth charts are provided only as a guide, if a specific weight criteria is needed please order animals by weight.
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Licensing
Terms of Sale and Use for ICR scid
These models are sold subject to Taconic's Terms and Conditions for Taconic's Models, Products and Services
Pricing - USD
Opportunist Free (OF) Health Standard
ICRSC Female
ICRSC-F Genotype sp/sp
| Age in Weeks | Quantity 1 - 99 | Quantity 100 - 999 |
| 3 to 5 | $67.00 | $62.00 |
| 6 to 8 | $81.00 | $74.00 |
| 9 | $94.00 | $85.00 |
Specialized Inventory
| ICRSC-FL | Quantity 1 - 199 |
| Female With Litter | $482.00 |
Specialized Inventory
| ICRSC-UP | Quantity 1 - 199 |
| Untimed Pregnant Female | $446.00 |
*Untimed pregnant requests are filled with late gestation pregnant females. Pups may be delivered in transit.
ICRSC Male
ICRSC-M Genotype sp/sp
| Age in Weeks | Quantity 1 - 99 | Quantity 100 - 999 |
| 3 to 5 | $67.00 | $62.00 |
| 6 to 8 | $81.00 | $74.00 |
| 9 | $94.00 | $85.00 |
Pricing - EUR
Opportunist Free (OF) Health Standard
ICRSC Female
ICRSC-F Genotype sp/sp
| Age in Weeks | Quantity 1 - 999 |
| 3 to 5 | €92,00 |
| 6 to 8 | €101,00 |
| 9 | €113,00 |
Specialized Inventory
| ICRSC-UP | Quantity 1 - 199 |
| Untimed Pregnant Female | €631,00 |
*Untimed pregnant requests are filled with late gestation pregnant females. Pups may be delivered in transit.
ICRSC Male
ICRSC-M Genotype sp/sp
| Age in Weeks | Quantity 1 - 999 |
| 3 to 5 | €92,00 |
| 6 to 8 | €101,00 |
| 9 | €113,00 |
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