| Model No. | Nomenclature | Genotype |
|---|---|---|
| NIHRNU-F | NTac:NIH-Foxn1rnu | sp/sp |
| NIHRNU-M | NTac:NIH-Foxn1rnu | sp/sp |
| NIHRNU-F | NTac:NIH-Foxn1rnu | sp/wt |
| NIHRNU-M | NTac:NIH-Foxn1rnu | sp/wt |
NIH nude rat
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Overview
Nomenclature: NTac:NIH-Foxn1rnu
- Exhibits deficient T cell activity with lymph nodes and Peyers patches showing lymphocyte depletion in T-lymphocyte dependent regions
- In this outbred immunodeficient model the vibrissae are present in the homozygous nude rat but bent with some short hairs on the head and occasionally on the rest of the body
- At later ages some hair growth occurs but rats become hairless again within a few weeks
- Skin of homozygous rat is generally pigmented, but occasionally an albino rat is seen
- Consistent with ILAR nomenclature rules, Taconic has recently updated the nomenclature for the NIHRNU from NTac:NIH-Whn to NTac:NIH-Foxn1rnu.
- Taconic has identified a defect in tooth enamel in the NIHRNU, which presents as white teeth in affected animals. This defect does/does not affect overall health of affected animals. Representative sampling of NIHRNU animals in our colonies revealed that on average 21% (frequency: 0.208 +/- 0.109 SD) of animals showed this phenotype.
Origin
The NIH nude Spontaneous mutant model was developed by NIH in 1979-1980 by intercrossing eight strains of rats. Taconic received stock from NIH Animal Genetic Resource in 1981. The rats were derived by hysterectomy in 1987 and again in 1998. Animals are randomly bred at Taconic without selection for coat color or pigmentation.
Genetics
Guides & Publications
Applications & Therapeutic Areas
- Cell and Tissue Humanized
- Immunology
- Inflammation
- Oncology & Immuno-Oncology
Transit, Housing & Welfare
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Packing Practices
Taconic standard practice is to recombine animals of different home cages and/or ages from a single model and sex during packing, except in specific cases where Taconic's animal welfare policy prohibits recombination due to aggression or other concerns. When an order is fulfilled with animals from more than one week of birth, this standard practice results in animals from a range of birth weeks packed together in a single TTC. When an order is fulfilled with animals from genotyped models, this standard practice results in animals from different home cages packed together in a single TTC.
Customers who wish to keep animals from different weeks of birth separated should place orders with the special instruction "Divide and label by age." Note that this special request can result in increased costs for additional Taconic Transit Cages, dividers and/or freight charges.
Taconic discourages other types of custom packing requests as they can have a negative impact on animal welfare. Learn more.
Diet
Data
Average litter size: 8
For some applications, weight may be critical. For orders where weight is critical, please place orders by weight, not by age. Taconic can accept orders by weight for this model. For orders sourced from US or Denmark a production minimum 15 gram span is accepted. All weights are weights at time of packing. Mice and rats can lose weight in transit. Orders for specific weight spans will be assessed a nominal fee. More detail on weight order policies is available.
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- Pricing - USD
- Pricing - EUR
- Pricing - USD Nonprofit
- Pricing - EUR Nonprofit
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Pricing - USD
Opportunist Free (OF) Health Standard
NIHRNU Female
NIHRNU-F Genotype sp/sp
| Age in Weeks | Quantity 1 - 999 |
| 3 to 4 | $285.00 |
| 5 to 8 | $358.00 |
| 9 to 12 | $401.00 |
NIHRNU-F Genotype sp/wt
| Age in Weeks | Quantity 1 - 999 |
| 3 to 12 | $150.00 |
Specialized Inventory
| NIHRNU-RF Genotype sp/wt | Quantity 1 - 199 |
| Retired Female Breeder | $286.00 |
Specialized Inventory
| NIHRNU-UP | Quantity 1 - 199 |
| Untimed Pregnant Female | $2,144.00 |
*Untimed pregnant requests are filled with late gestation pregnant females. Pups may be delivered in transit.
Specialized Inventory
| NIHRNU-FL | Quantity 1 - 199 |
| Female With Litter | $2,476.00 |
NIHRNU Male
NIHRNU-M Genotype sp/sp
| Age in Weeks | Quantity 1 - 999 |
| 3 to 4 | $285.00 |
| 5 to 8 | $358.00 |
| 9 to 12 | $401.00 |
NIHRNU-M Genotype sp/wt
| Age in Weeks | Quantity 1 - 999 |
| 3 to 12 | $150.00 |
Specialized Inventory
| NIHRNU-RM Genotype sp/sp | Quantity 1 - 199 |
| Retired Male Breeder | $286.00 |
Pricing - EUR
Opportunist Free (OF) Health Standard
NIHRNU Female
NIHRNU-F Genotype sp/sp
| Age in Weeks | Quantity 1 - 999 |
| 3 to 4 | €290,00 |
| 5 to 8 | €342,00 |
| 9 to 12 | €401,00 |
NIHRNU-F Genotype sp/wt
| Age in Weeks | Quantity 1 - 999 |
| 4 to 12 | €151,00 |
Specialized Inventory
| NIHRNU-RF Genotype sp/wt | Quantity 1 - 199 |
| Retired Female Breeder | €200,00 |
Specialized Inventory
| NIHRNU-UP | Quantity 1 - 199 |
| Untimed Pregnant Female | €1.541,00 |
*Untimed pregnant requests are filled with late gestation pregnant females. Pups may be delivered in transit.
Specialized Inventory
| NIHRNU-FL | Quantity 1 - 199 |
| Female With Litter | €2.524,00 |
NIHRNU Male
NIHRNU-M Genotype sp/sp
| Age in Weeks | Quantity 1 - 999 |
| 3 to 4 | €290,00 |
| 5 to 8 | €342,00 |
| 9 to 12 | €401,00 |
NIHRNU-M Genotype sp/wt
| Age in Weeks | Quantity 1 - 999 |
| 4 to 12 | €151,00 |
Specialized Inventory
| NIHRNU-RM Genotype sp/sp | Quantity 1 - 199 |
| Retired Male Breeder | €401,00 |
Pricing - USD Nonprofit
Opportunist Free (OF) Health Standard
NIHRNU Female
NIHRNU-F Genotype sp/sp
| Age in Weeks | Quantity 1 - 999 |
| 3 to 4 | $256.00 |
| 5 to 8 | $322.00 |
| 9 to 12 | $361.00 |
NIHRNU-F Genotype sp/wt
| Age in Weeks | Quantity 1 - 999 |
| 3 to 12 | $135.00 |
Specialized Inventory
| NIHRNU-RF Genotype sp/wt | Quantity 1 - 199 |
| Retired Female Breeder | $286.00 |
Specialized Inventory
| NIHRNU-UP | Quantity 1 - 199 |
| Untimed Pregnant Female | $2,144.00 |
*Untimed pregnant requests are filled with late gestation pregnant females. Pups may be delivered in transit.
Specialized Inventory
| NIHRNU-FL | Quantity 1 - 199 |
| Female With Litter | $2,476.00 |
NIHRNU Male
NIHRNU-M Genotype sp/sp
| Age in Weeks | Quantity 1 - 999 |
| 3 to 4 | $256.00 |
| 5 to 8 | $322.00 |
| 9 to 12 | $361.00 |
NIHRNU-M Genotype sp/wt
| Age in Weeks | Quantity 1 - 999 |
| 3 to 12 | $135.00 |
Pricing - EUR Nonprofit
Opportunist Free (OF) Health Standard
NIHRNU Female
NIHRNU-F Genotype sp/sp
| Age in Weeks | Quantity 1 - 999 |
| 3 to 4 | €261,00 |
| 5 to 8 | €308,00 |
| 9 to 12 | €361,00 |
NIHRNU-F Genotype sp/wt
| Age in Weeks | Quantity 1 - 999 |
| 4 to 12 | €136,00 |
Specialized Inventory
| NIHRNU-RF Genotype sp/wt | Quantity 1 - 199 |
| Retired Female Breeder | €200,00 |
Specialized Inventory
| NIHRNU-UP | Quantity 1 - 199 |
| Untimed Pregnant Female | €1.541,00 |
*Untimed pregnant requests are filled with late gestation pregnant females. Pups may be delivered in transit.
Specialized Inventory
| NIHRNU-FL | Quantity 1 - 199 |
| Female With Litter | €2.524,00 |
NIHRNU Male
NIHRNU-M Genotype sp/sp
| Age in Weeks | Quantity 1 - 999 |
| 3 to 4 | €261,00 |
| 5 to 8 | €308,00 |
| 9 to 12 | €361,00 |
NIHRNU-M Genotype sp/wt
| Age in Weeks | Quantity 1 - 999 |
| 4 to 12 | €136,00 |
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